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HDAC1 — PTGS2

Text-mined interactions from Literome

Tong et al., Biochem Biophys Res Commun 2004 (Colonic Neoplasms) : The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells
Tong et al., J Biol Chem 2005 (Colonic Neoplasms) : Moreover, we found that the histone deacetylase inhibitors butyrate and trichostatin A could block Cox-2 activation in a gene-specific manner
Yamaguchi et al., J Biol Chem 2005 : We investigated whether HDAC inhibitors blocked AP-1 mediated activation of COX-2 transcription ... Chromatin immunoprecipitation assays indicated that HDAC inhibitors suppressed c-Jun binding to the COX-2 promoter and thereby blocked transcription
Cao et al., Am J Respir Cell Mol Biol 2007 : COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1 ... These results show for the first time acetylation via selective degradation of HDAC1 , and that recruitment of HAT plays an important role in DEP induced expression of the COX-2 gene
Liu et al., J Cell Biochem 2010 : Here, we found that an inhibitor of histone deacetylase (HDAC) , trichostatin A (TSA), can not repress LPS induced COX-2 but it increased the COX-2 level in RAW264.7 cells
Fernández-Alvarez et al., Oncogenesis 2012 : We also examined the acetylation status of the COX-2 promoter and the effects of histone deacetylase (HDAC) inhibitors on COX-2 expression
Cho et al., Immune network 2013 : Both IL-4 and HDAC inhibitors suppressed COX-2 expression in dose dependent manners