◀ Back to STAT3

IL24 — STAT3

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Chada et al., Int Immunopharmacol 2004 : In human peripheral blood mononuclear cells ( PBMC ), STAT3 activation by MDA-7/IL-24 is followed by elaboration of secondary Th1 cytokines, demonstrating that MDA-7/IL-24 is a pro-Th1 cytokine
Chada et al., Mol Ther 2004 (Melanoma) : In normal cells, MDA-7 can bind to its cognate receptors and induce phosphorylation of STAT3 , without cytotoxic sequelae
Wang et al., Immunology 2005 (Neoplasms...) : Upon binding to its receptors, IL-24 induces rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation
Kreis et al., PloS one 2007 (Melanoma) : Binding of IL-24 to either of its two possible heterodimeric receptors IL-20R1/IL-20R2 and IL-22R/IL-20R2 activates STAT3 and/or STAT1 in target tissues such as lung, testis, ovary, keratinocytes and skin ... Results for three cell lines contrasted with previous studies, which reported presence of IL-24 receptors and activation of STAT3 following IL-24 stimulation
Sainz-Perez et al., J Immunol 2008 (Leukemia, Lymphocytic, Chronic, B-Cell) : In contrast, IL-24 reversed the IL-2 induced phosphorylation of STAT3 in CLL, and this effect was neutralized by anti-IL-24 Ab. Phospho- ( P ) STAT3 inhibition induced by IL-24 was reversed by pervanadate, an inhibitor of tyrosine phosphatases
Andoh et al., J Immunol 2009 (Inflammatory Bowel Diseases...) : IL-24 induced JAK1/STAT-3 phosphorylation and SOCS3 expression in HT-29 colonic epithelial cells
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin