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Schmitz et al., Eur J Clin Invest 2001
(Colorectal Neoplasms) :
Mutation 287V -- > F is associated with a loss of gastrin induced MAPK p44/p42 signalling in Colo 320 cells while clonal expansion from single cells is increased by 53.1 +/- 15.9 % when compared to Colo 320 cells expressing wild-type CCK-B/gastrin receptors
Moore et al., Regul Pept 2004
(Adenocarcinoma...) :
Gastrin induced phosphorylation of the p44 and p42 mitogen activated protein kinases was demonstrated by Western blot analysis