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EPHB2 — FSHR
Text-mined interactions from Literome
Piketty et al., Reproductive biology and endocrinology : RB&E 2006
:
Upon FSH stimulation, the
FSH-R activates the extracellular signal regulated kinases (
ERK ) ... In the present study, we examined the ability of the FSH activated
FSH-R to
induce ERK phosphorylation, in conditions where its beta-arrestin- and dynamin mediated internalization was impaired ... From these results, we conclude that the
FSH-R does not
require beta-arrestin- nor dynamin mediated internalization to initiate
ERK phosphorylation in response to FSH
Kara et al., Mol Endocrinol 2006
:
Here, we show that the
FSH-R expressed in HEK 293 cells
activated ERK by two temporally distinct pathways dependent, respectively, on Galpha ( s ) /PKA and beta-arrestins ... G protein coupled receptor kinase 5 ( GRK5 ) and GRK6 were
required for beta-arrestin dependent
ERK activation by both the wild-type and 5A
FSH-R ... In conclusion, we demonstrate the existence of a beta-arrestin dependent, GRK regulated mechanism for
ERK activation by the
FSH-R