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BIRC5 — CASP10
Text-mined interactions from Literome
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )