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IL10 — PIK3R1
Text-mined interactions from Literome
Williams et al., J Immunol 2004
(Disease Susceptibility...) :
Inhibition of
PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6,
IL-10 , IL-12, and TNF-alpha in septic mice
Merck et al., Blood 2005
:
A
PI3K dependent up-regulation of
IL-10 release is observed with all the TLR ligands used, whereas regulation of IL-12 production is variable depending on the TLR stimulated
Rahimi et al., J Immunol 2005
:
IL-10 induced the phosphorylation of
PI3K and p42/44 ERK MAPK
Saegusa et al., Mol Immunol 2007
:
A specific ERK inhibitor, U0126, as well as
PI3K inhibitors, differentially
regulated IL-10 and IL-12 p70 productions ... These results suggest that
PI3K positively and negatively
regulates the production of CpG-ODN induced
IL-10 and IL-12 p70, respectively, and negatively regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
Lambert et al., J Immunol 2007
:
To test the hypothesis that
PI3K , which acts upstream of mammalian target of rapamycin, might also be
involved in LMP1 dependent
IL-10 production, we generated B cell lines expressing signaling-inducible chimeric LMP1 ... Our results show that induced LMP1 signaling elicits both p38- and
PI3K dependent
IL-10 production in EBV- B cells ... We also demonstrate that the LMP1 dependent p38 and
PI3K activation
regulates IL-10 induction through discrete mechanisms
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Hoarau et al., PloS one 2008
(Hypersensitivity...) :
We found that 1 ) the PI3K pathway was positively involved in the prolonged DC survival induced by BbC50sn, LPS and Zymosan in contrast to p38MAPK and GSK3 which negatively regulated DC survival ; 2 ) p38MAPK and PI3K were positively involved in DC maturation, in contrast to ERK and GSK3 which negatively regulated DC maturation ; 3 ) ERK and
PI3K were positively
involved in
DC-IL-10 production, in contrast to GSK3 that was positively involved in DC-IL-12 production whereas p38MAPK was positively involved in both ; 4 ) BbC50sn induced a PI3K/Akt phosphorylation similar to Zymosan and a p38MAPK phosphorylation similar to LPS
Garcia et al., J Immunol 2009
:
In the present study, we demonstrate that IL-12p70 induces
IL-10 production from human memory CD4+ T cells via a
PI3K dependent signaling mechanism ... Inhibition of
PI3K prevented the inactivation of GSK3beta by IL-12p70, as well as the subsequent ability of IL-12p70 to augment
IL-10 levels by memory CD4+ T cells
Dutra et al., Br J Pharmacol 2011
(Colitis) :
Importantly, the
PI3K? inhibitor also
up-regulated IL-10 , CD25 and FoxP3 expression
Antoniv et al., Immunology 2011
:
Phosphatidylinositol 3-kinase (PI3K) -mediated signalling regulates inflammatory responses and can
induce IL-10 production, but a role for
PI3K signalling in cellular responses to IL-10 is not known
Gentle et al., J Immunol 2012
:
Modulation required de novo protein synthesis, and PI3K, JNK, and ERK activity were necessary for enhanced IL-2 expression, whereas modulation of
IL-10 required only
PI3K activity
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate
PI3K/Akt signaling and
induce IL-10 production
Tapia-Abellán et al., Liver Int 2013
(Liver Cirrhosis) :
The release of the pro-inflammatory cytokines IL-6 and TNF-a at baseline was more effectively reduced by the MAPK inhibitors, while the basal
IL-10 anti-inflammatory cytokine secretion was only and strongly ( 90.3 % )
affected by the
PI3K inhibitor ... Finally, inhibition of
PI3K almost completely
suppressed the secretion of
IL-10 in stimulated M-DM
Bavelloni et al., J Cell Sci 1999
(Osteosarcoma) :
Phosphatidylinositol 3-kinase translocation to the nucleus is
induced by
interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells