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ERBB2 — NFKB1

Text-mined interactions from Literome

Guo et al., Oncogene 2004 : Expression of ErbB2 enhances radiation induced NF-kappaB activation ... Stable transfection of dominant negative mutant IkappaB ( MCF-7/ErbB2/mIkappaB ) or treatment with anti-ErbB2 antibody, Herceptin, inhibited NF-kappaB activation and radiosensitized MCF-7/ErbB2 cells ... To identify specific genes affected by ErbB2 mediated NF-kappaB activation, a group of IR-responsive elements Cyclin B1, Cyclin D1, Bcl-2, Bcl/XL, BAD and BAX were evaluated ... These results thus provide evidence suggesting that overexpression of ErbB2 is able to enhance NF-kappaB response to IR, and that a specific prosurvival network downstream of NF-kappaB is triggered by treatments using anti-ErbB2 antibody combined with radiation
Tan et al., Cancer Res 2005 (Breast Neoplasms...) : Our studies revealed two novel mechanisms that are involved in Src protein up-regulation and activation by ErbB2 : ( a ) ErbB2 increased Src translation through activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway and ( b ) ErbB2 increased Src stability most likely through the inhibition of the calpain protease
Rivas et al., Breast Cancer Res Treat 2010 (Breast Neoplasms...) : Inhibition of ErbB-2 by addition of AG825, an epidermal growth factor receptor/ErbB-2-tyrosine kinase inhibitor, or knockdown of ErbB-2 by RNA interference strategy, blocked TNFalpha induced NF-kappaB activation and proliferation