◀ Back to IFNB1

IFNB1 — MYD88

Pathways - manually collected, often from reviews:

• KEGG Tuberculosis: MYD88 → IFNB1 (gene expression, expression)

Text-mined interactions from Literome

Schilling et al., J Immunol 2002 : TLR4 dependent induction of IL-6 expression did require Toll-IL-1R domain containing adapter protein ( TIRAP ) /MyD88 adapter-like (Mal) , but unlike iNOS and IP-10, it did not require the expression of IFN-beta
Yamamoto et al., J Immunol 2002 : Furthermore, TRIF, but neither MyD88 nor TIRAP, activated the IFN-beta promoter
Oshiumi et al., J Biol Chem 2003 : Although MyD88 and Mal/TIRAP adapters functions downstream of TLR4, DC maturation and IFN-beta induction are independent of MyD88 and Mal/TIRAP
Sugiyama et al., Microbiol Immunol 2004 : These results suggested that 2-AP inhibited LPS induced IFN-beta production by preventing Toll/IL-1 receptor domain containing adaptor inducing IFN-beta ( TRIF ) -dependent signaling rather than myeloid differentiation factor (MyD) 88-dependent signaling, resulting in the inhibition of NO production
Hirotani et al., Biochem Biophys Res Commun 2005 : Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta
Toshchakov et al., J Immunol 2005 (MAP Kinase Signaling System) : We designed a set of `` blocking peptides '' ( BPs ) comprised of the 14 aa that correspond to the sequences of the BB loops of the four known Toll-IL-1 resistance ( TIR ) domain containing adapter proteins ( i.e., MyD88 , TIR domain containing adapter inducing IFN-beta ( TRIF ), TRIF related adapter molecule (TRAM), and TIR-domain containing adapter protein ( TIRAP ) ) linked to the cell penetrating segment of the antennapedia homeodomain
Zhang et al., J Immunol 2009 (Multiple Sclerosis, Relapsing-Remitting) : Using small interfering RNA TLR7 gene silencing, we confirmed that IFN-beta1a induced changes in MyD88 , IL-1R associated kinase 4, and IL-1R expression were dependent on TLR7
Siegemund et al., J Virol 2009 : iPPVO elicits IFN-alpha/beta by Toll-like receptor ( TLR ) -independent pathways in BM-cDC, since IFN-alpha/beta release does not require myeloid differentiation primary response gene 88 ( MyD88 ) or TIR-domain containing adaptor protein inducing interferon ( TRIF )
Burns et al., J Immunol 2010 (Bacteroidaceae Infections) : Proinflammatory cytokine production in response to P. gingivalis infection depends on TLR2, but it does not require MyD88 or TLR/IL-1R-domain containing adaptor inducing IFN-beta
Tam et al., Immunology 2009 (Listeriosis) : Together the data suggest an inhibitory effect of IFN-alpha/beta on functional DC maturation during Listeria infection and reveal overlapping roles of MyD88 induced cytokines and IFN-alpha/beta in DC maturation and protective anti-Listeria immunity
Prantner et al., J Immunol 2010 : Previous studies have demonstrated no role for TLR4 and a partial role for MyD88 in chlamydial induced IFN-beta
Liu et al., J Immunol 2010 : Zebrafish Myd88 alone strongly induced the activation of NF-kappaB and IFN-beta both in HEK293T and carp leukocyte cells
Gratz et al., PLoS Pathog 2011 (Cellulitis) : Macrophages required IRF3, STING, TBK1 and partially MyD88, whereas in cDCs the IFN-beta production was fully dependent on IRF5 and MyD88