Harrington et al., J Biol Chem 2008
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Because p75 lacks the GDP/GTP exchange factor domain, it has remained unclear how p75 activates RhoA Stiles et al., J Cell Sci 2013
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Mechanistic studies in N2a cells showed that LRP1 and p75NTR associate in a MAG dependent manner and that MAG mediated activation of RhoA may involve both LRP1 and p75NTR