Gene interactions and pathways from curated databases and text-mining

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IL8 — PPARA

Text-mined interactions from Literome

Shu et al., Biochem Biophys Res Commun 2000 : Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
Xie et al., J Cardiovasc Pharmacol 2005 : The activation of PPARalpha/gamma can negatively regulate C-reactive protein induced IL-8 production in human monocytes
Borland et al., Cell Signal 2011 : However, these studies demonstrate that stable over-expression of PPARß/d or PPAR? significantly increases the efficacy of ligand activation and represses UVB induced expression of tumor necrosis factor a (TNFa), interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes
Martín et al., J Hypertens 2012 : In addition, pioglitazone increased the interleukin-1ß induced PPAR? mRNA levels