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DKK3 — WNT4

Text-mined interactions from Literome

Holmen et al., Biochem Biophys Res Commun 2005 : Dkk1, but not the related Dkk3 , binds LRP6 and inhibits canonical Wnt signaling by blocking the interaction of Wnt and LRP6
Nakamura et al., BMC cell biology 2007 (Retinal Degeneration) : We demonstrated that Dkk3 potentiated Wnt signaling in Müller glia and HEK293 cells but not in COS7 cells, indicating that it is a cell-type specific regulator of Wnt signaling
Ding et al., World J Gastroenterol 2009 (Carcinoma, Hepatocellular...) : DKK-3 and WIF-1 acted as Wnt-antagonists and tumor suppressors, but hypermethylation of the gene promoter and low mRNA expression activated Wnt signaling aberrantly and induced the development of HCC
Bao et al., Science signaling 2012 : The structural basis of DKK mediated inhibition of Wnt/LRP signaling
Onai et al., Evol Dev 2012 (Wnt Signaling Pathway) : The resemblance of the headless phenotype to that from upregulation of Wnt/ß-catenin signaling with BIO, a GSK3ß inhibitor, suggested that Dkk3 might inhibit Wnt/ß-catenin signaling ... We conclude that amphioxus Dkk3 regulates head formation by modulating both Wnt/ß-catenin and Nodal signaling, and that these functions may have been partitioned among various vertebrate lineages during evolution of Dkk3 proteins
Chang et al., PloS one 2012 : DKK , an inhibitor of Wnt signaling, abolished Wnt3a induced effect but did not interfere GSK-3ß/14-3-3s binding
Zhu et al., Carcinogenesis 2012 (Neoplasm Invasiveness...) : Furthermore, epigenetic modification of the Dickkopf ( DKK ) family ( DKK1-DKK4 ) has been shown to be important in Wnt signaling regulation
Tamura et al., Clinical calcium 2013 (Wnt Signaling Pathway) : Recently, numerous studies suggest that PTH enhances bone formation through the suppression of sclerostin, DKK1 and sFRP1, inhibitors of Wnt-ß-catenin signal