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ERBB3 — MYLIP
Text-mined interactions from Literome
Wu et al., Cell Res 2009
(Breast Neoplasms...) :
Finally, western blot combined with the luciferase reporter assays demonstrate that
ErbB3 and vascular endothelial growth factor A ( VEGF-A ) are direct
targets for
miR-205 , and this miR-205 mediated suppression is likely through the direct interaction with the putative miR-205 binding site in the 3'-untranslated region ( 3'-UTR ) of ErbB3 and VEGF-A
Momose et al., Genes Cells 2013
:
miR-214 and hypoxia down-regulate Necl-2/CADM1 and
enhance ErbB2/ErbB3 signaling ...
miR-214 , that is frequently up-regulated in a variety of cancers, targeted the 3'UTR of the Necl-2 mRNA directly, suppressed the translation of Necl-2 and
enhanced the ligand induced
ErbB2/ErbB3 signaling in human colon cancer Caco-2 cells ... These results indicate that
miR-214 and hypoxia are novel regulators that down-regulate Necl-2 and
enhance ErbB2/ErbB3 signaling
Minami et al., J Biol Chem 2013
(Lung Neoplasms) :
In addition,
miR-199a enhanced the HRG induced
ErbB2/ErbB3 signaling ... These results indicate that the suppressive role of Necl-2 in the HRG induced
ErbB2/ErbB3 signaling is
regulated by
miR-199a at least through the reduction of the ST6GAL1 catalyzed sialylation of Necl-2 and/or through the reduction of the protein level of Necl-2 presumably by the protein degradation