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GP5 — NR1I2

Text-mined interactions from Literome

Takara et al., Biochem Biophys Res Commun 2003 (Adenocarcinoma...) : A steroid xenobiotic receptor (SXR) is involved in the induction of MDR1/P-glycoprotein
Bauer et al., Mol Pharmacol 2004 : In liver, ligand activated, nuclear receptors are transcriptional regulators of drug metabolizing enzymes and drug export pumps, but only one, the pregnane X receptor ( PXR in rodents, SXR in humans ), regulates p-glycoprotein expression
Bauer et al., Mol Pharmacol 2006 : Previous studies in rat showed that brain capillary P-glycoprotein was transcriptionally up-regulated by the pregnane X receptor (PXR) , a xenobiotic activated nuclear receptor
Schwarz et al., Clin Pharmacol Ther 2007 : St John 's wort ( SJW ) is known to induce cytochrome P450 (CYP) 3A4 and P-glycoprotein through pregnane X-receptor activation
Nowack et al., Nephrology (Carlton) 2008 : The interaction mechanisms of St. John 's Wort by pregnane X-receptor mediated upregulation of cytochrome-P450 enzyme 3A4 and p-glycoprotein expression and of grapefruit juice by mechanism based inhibition of intestinal CYP3A4 suggest that many other plant products will likewise cause interactions with drugs because they occupy the same metabolic pathways
Ott et al., J Pharmacol Exp Ther 2009 : Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier : functional similarities between pig and human PXR
Zhang et al., Invest Ophthalmol Vis Sci 2012 : Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid receptor and pregnane X receptor