◀ Back to TNF

FOS — TNF

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: FOS/JUN → TNF (protein-protein, expression)

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : Beta-lapachone also abolished TNF induced activation of AP-1 , c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Feng et al., Infect Immun 1999 : The high-level expression of TNF-alpha persisted over 2 h. Dexamethasone blocked the activation of both NF-kappaB and AP-1 and suppressed the production of TNF-alpha in TEP macrophages stimulated by M. penetrans lipid extract of PK-digested LAMPs
Soto et al., Oncogene 1999 (Neoplasm Invasiveness) : Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-alpha mediated repression of viral transcription and modification of the AP-1 transcription complex
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : TNF-alpha stimulation enhanced AP-1 and induced NF-KB but no NF-IL6 DNA binding in these cells
Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Andoh et al., Clin Exp Immunol 1999 : The EMSAs indicated that sodium butyrate suppressed TNF-alpha induced nuclear factor (NF)-kappaB- and activation protein (AP)-1-DNA binding activity, but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity
Abe et al., Am J Respir Cell Mol Biol 2000 : In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha treated BET-1A cells ; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells
Gertzberg et al., Am J Respir Cell Mol Biol 2000 : We tested the hypothesis that protein kinase ( PK ) G activation in response to nitric oxide ( ( * ) NO ) mediates tumor necrosis factor (TNF)-alpha induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers ( PEM ) ... TNF treatment ( 1,000 U/ml ) for 4 h induced a significant increase in DNA binding of AP-1
Seppänen et al., Eur J Endocrinol 2000 (Cystadenocarcinoma...) : The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines, TGF-beta1 and TNF-alpha, and the binding of NF-kappaB was stimulated by TNF-alpha
Manna et al., J Biol Chem 2000 : Protein tyrosine kinase p56lck is required for ceramide induced but not tumor necrosis factor induced activation of NF-kappa B, AP-1 , JNK, and apoptosis ... p56 ( lck ) was also found to be required for ceramide induced but not TNF induced AP-1 activation
Manna et al., J Biol Chem 2000 : AP-1 activation induced by TNF and ceramide was also suppressed by hCG
Manna et al., J Immunol 2000 : p56lck was also found to be required for HIV-tat induced but not TNF induced AP-1 activation
Manna et al., Oncogene 2000 (Lung Neoplasms) : The increase in TNF receptors sensitized H596 cells to TNF induced activation of NF-kappaB, AP-1 and apoptosis ... A549 cells, however, were completely resistant to TNF induced activation of NF-kappaB, AP-1 and apoptosis
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Vallejo et al., J Immunol 2000 (MAP Kinase Signaling System) : These results indicate that both NF-kappaB and AP-1 ( via p38 MAPK ) are involved in the regulation of TNF-alpha production in GBS stimulated neonatal monocytes
Chainy et al., Oncogene 2000 : Besides NF-kappaB, anethole also suppressed TNF induced activation of the transcription factor AP-1 , c-jun N-terminal kinase and MAPK-kinase
Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Hirota et al., Biochem Biophys Res Commun 2000 : We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1 , and CREB activation induced by TNFalpha , PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells
Manna et al., Cancer Res 2000 : Oleandrin also blocked AP-1 activation induced by TNF and other agents and inhibited the TNF induced activation of c-Jun NH2-terminal kinase
González et al., J Cell Biol 2000 : Our results show that glucocorticoids antagonize the TNF-alpha induced activation of AP-1 by causing the accumulation of inactive JNK without affecting its subcellular distribution
Rahman et al., Biochem Pharmacol 2000 (Lung Diseases) : The promoter regions of the human gamma-GCS subunits contain AP-1 , NF-kappa B, and antioxidant response elements and are regulated by oxidants, growth factors, inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) , and anti-inflammatory agent ( dexamethasone ) in lung cells ... TNF-alpha also induces the activation of NF-kappa B and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells
Manna et al., J Immunol 2000 : Leflunomide also inhibited TNF induced activation of AP-1 and the c-Jun N-terminal protein kinase activation
Yarosh et al., Photodermatol Photoimmunol Photomed 2000 : Induction of membrane bound TNFalpha was also found in c-fos gene knockout mice deficient in the AP-1 transcription factor, suggesting that, although AP-1 containing c-fos signaling is required for some UV responses, AP-1 containing c-fos is not required for this TNFalpha activation
Shrivastava et al., Antioxid Redox Signal 1999 : In contrast, none of the radical quenchers had any significant effect on TNF induced AP-1 activation ... In this report, we investigated the effect of various superoxide radical quenchers -- pyrrolidine dithiocarbamate ( PDTC ), N-acetyl-L-cysteine (NAC), and glutathione ( GSH ) -- an hydroxyl radical quencher ( mannitol ), and lipid peroxide quenchers -- butylated hydroxytoluene ( BHT ) and butylated hydroxyanisole ( BHA ) -- on TNF induced activation of nuclear transcription factors-kappa B ( NF-kappa B ) and activator protein-1 (AP-1) , c-jun amino-terminal kinase ( JNK ), and apoptosis in human monocytic U937 cells ... Overall, these results suggest that hydroxyl radicals mediate TNF induced apoptosis but not activation of NF-kappa B, AP-1 , and JNK ; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis ; and lipid peroxides are required for all the signals induced by TNF
Emch et al., Am J Physiol Regul Integr Comp Physiol 2001 : TNF-alpha induced c-Fos generation in the nucleus of the solitary tract is blocked by NBQX and MK-801
Nakamura et al., J Am Soc Nephrol 2001 : The increase in TNF-alpha was attenuated by both a p42/p44 inhibitor, PD098059 ( 10 ( -6 ) M ), and a p38 inhibitor, SB203580 ( 10 ( -6 ) M ), and AP-1 binding activity was inhibited by PD098059
Bischof et al., Early pregnancy (Online) 2001 : Among these we identified two oncogene products ( Jun and Fos ) which were activated by TNF or phorbol esters and which promoted the synthesis of MMP-9
Mukhopadhyay et al., Oncogene 2001 (Prostatic Neoplasms) : TNF induced NF-kappaB activation but not AP-1 activation in LNCaP cells
Ortiz et al., Am J Physiol Lung Cell Mol Physiol 2002 (Body Weight...) : Enalapril protects mice from pulmonary hypertension by inhibiting TNF mediated activation of NF-kappaB and AP-1
Takeshita et al., J Oral Sci 2002 : The present study suggests a regulatory interference by 1alpha25 ( OH ) 2D3 for RA inhibition of TNF-alpha induced AP-1 activity in osteoblasts
Rahman et al., Mol Cell Biochem 2002 (Inflammation) : Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation ... H2O2, and TNF-a , and TSA all increased NF-kappaB and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Flora et al., Neuromolecular Med 2002 (Inflammation) : Methamphetamine induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain : potential role of reactive oxygen intermediates and lipid peroxidation
Borgmann et al., Endothelium : journal of endothelial cell research 2002 : Alteration of cytokine release was accompanied by reduced basal and TNF-alpha stimulated nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activity
Higuchi et al., Antioxid Redox Signal 2002 (Leukemia, Myeloid, Acute) : Additionally, tumor necrosis factor (TNF) induced activation of NF-kappaB and AP-1 observed in ML-1a was greatly reduced in clone 19
Chen et al., Kidney Int 2003 : In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation ... The present data indicate that TNF-alpha activation of PKCzeta/iota, p42/44 MAPK, c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression, with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro
Yuksel et al., J Pharmacol Exp Ther 2003 : These observations strongly suggest that gabexate mesilate inhibited LPS induced TNF-alpha production in human monocytes by inhibiting activation of both NF-kappaB and AP-1
Ventura et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : c-Jun NH ( 2 ) -terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor ... We show that JNK is required for the normal regulation of AP-1 by TNF
Lee et al., Br J Pharmacol 2003 : The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase 2 (COX-2) gene expression and on the activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP), activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects
Kähäri et al., J Biol Chem 1992 : These observations suggest that the inhibitory effects of TNF-alpha on elastin gene expression involve the transcription factor AP-1
Chiu et al., Chin J Physiol 2002 : Moreover, in ECs either presheared or remained in a static condition prior to stimulation by TNF-alpha while under shear flow, the ability of TNF-alpha to induce AP-1-DNA binding activity in the nucleus was reduced
Lagoumintzis et al., Infect Immun 2003 : Activation of NF-kappa B and AP-1 by P. aeruginosa GLP may be involved not only in TNF-alpha induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003 : To study the effect of nuclear transcription factor AP-1 on tumor necrosis factor alpha (TNF-alpha) or minimal modified low density lipoprotein ( mmLDL ) -induced expression of plasminogen activator inhibitor-1 ( PAI-1 ) in human vascular endothelial cells
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Yang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Tumor necrosis factor alpha (TNFalpha) , which activates both NF-kappa B and AP-1 , increased MAT2A expression in a dose- and time dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity, with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites
Arnott et al., Oncogene 2004 (Skin Neoplasms) : Keratinocyte derived TNF-alpha acts as an endogenous tumour promoter and can also regulate AP-1 activity in mouse epidermis
Takada et al., J Biol Chem 2004 : PTD-p65-P1 had no effect on TNF induced AP-1 activation
Yoshizumi et al., Exp Cell Res 2004 : Finally, TNF-alpha induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen
Park et al., Nephrol Dial Transplant 2004 : We investigated the role of NF-kappa B and AP-1 in tumour necrosis factor alpha (TNF-alpha) induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) ... ( i ) TNF-alpha increased NF-kappa B and AP-1 binding activity
Moon et al., J Cell Physiol 2004 : Furthermore, the transactivation of TNF-alpha stimulated NF-kappaB and AP-1 was inhibited by U0126 treatment ... Overexpression of RasN17 also abolished the TNF-alpha stimulated NF-kappaB and AP-1 activity
Chen et al., J Pharmacol Exp Ther 2004 : PD98059 abolished TNF-alpha activated p42/44 MAPK phosphorylation and c-Fos up-regulation, whereas SP600125 inhibited TNF-alpha activated JNK and c-Jun phosphorylation ... Finally, the pretreatment of VSMCs with PTX or cilostamide, but not denbufylline, reduced TNF-alpha induced CCL2/MCP-1 production, which was preceded by attenuation of p65/NF-kappaB nuclear translocation, p42/44 MAPK, and JNK-c-Jun phosphorylation, and c-Fos up-regulation
Rao et al., J Biol Chem 2004 (Breast Neoplasms...) : hCG treatment prevented the tumor necrosis factor dependent NF-kappaB and AP-1 activation, which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha
Ait-Ali et al., Mol Endocrinol 2004 : In addition, TNF-alpha increased the binding activity of activator protein-1 (AP-1) and stimulated transcription of a reporter gene containing AP-1-responsive elements in chromaffin cells
Granet et al., Cytokine 2004 : IL-1 and TNF-alpha induced egr-1 and all AP-1 member expression, except fosB and junD
Faggioli et al., Biochim Biophys Acta 2004 : In combination with p65 and/or C/EBPdelta, TAM-67 also synergistically activated the IL-6 promoter, while it inhibited TNF-alpha induced AP-1 activity directing an AP-1-responsive reporter plasmid
Reiterer et al., J Nutr 2004 (Inflammation) : However, if zinc was added back, all PPAR agonists significantly downregulated the TNF-alpha mediated induction of inflammatory transcription factors NF-kappaB and AP-1 and significantly reduced the expression of their target genes, VCAM-1 and IL-6
Cho et al., Int Immunopharmacol 2004 : In view of the potential role of AP-1 in the induction of TNF-alpha , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha
Okajima et al., Curr Vasc Pharmacol 2004 (Hypotension...) : APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha
Gauss et al., J Leukoc Biol 2005 : As p67phox can be up-regulated by tumor necrosis factor alpha (TNF-alpha) , which activates AP-1 , we hypothesized that TNF-alpha might regulate NCF2transcription via AP-1
Fichorova et al., Antimicrob Agents Chemother 2005 (Vaginitis) : Within 6 h of exposure, TNF-alpha and N-9 triggered NF-kappaB and AP-1/cFos activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells
Biswas et al., Antioxid Redox Signal 2005 : Curcumin inhibited both H2O2- and TNF-alpha mediated activation of NF-kappaB and AP-1 , and IL-8 release
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB
Siebert et al., Arthritis Rheum 2005 : TNFalpha induced activation of NF-kappaB and AP-1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation
Takeshita et al., J Oral Sci 2005 (Second Messenger Systems) : We previously demonstrated that tumor necrosis factor (TNF)-alpha stimulated the production of activation protein (AP)-1 , a transcriptional factor, in mouse osteoblastic MC3T3-E1 cells ... The present study thus suggests that SPP acts as a signal molecule in ceramide dependent signal transduction in TNF-alpha induced AP-1 in osteoblastic MC3T3-E1 cells
Yang et al., Biochem J 2005 : TNFalpha induces NF-kappaB ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2
Lee et al., Biochem Biophys Res Commun 2005 (Fibrosarcoma) : We also found that SM-7368 strongly inhibits TNF-alpha induced NF-kappaB activity but not AP-1 activity
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Bryce et al., Int Immunol 2006 (Hypersensitivity...) : We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF induced NF-kappaB and AP-1 signaling as well as TCR triggered proliferative responses in T cells
Shun et al., Ann Otol Rhinol Laryngol 2005 (Nasal Polyps) : A transient elevation of c-Fos and c-Jun messenger RNAs was induced by TNF-alpha , whereas COX-2 inhibitors NS-398 and meloxicam abolished the up-regulation of c-Fos ... The electrophoretic mobility shift assay revealed that TNF-alpha triggered AP-1 and DNA binding and again, NS-398 and meloxicam inhibited this reaction via reducing c-Fos synthesis
Lendemans et al., J Endotoxin Res 2006 : In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1
Asano et al., J Pharm Pharmacol 2006 : Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs, which were increased by TNF-alpha stimulation, through the suppression of NF-kappaB and AP-1 activation
Chen et al., Shock 2006 (Burns...) : Thermal injury also induces TNF-alpha dependent delay apoptosis and TNF-alpha independent AP-1 activation of neutrophil at 3 h after thermal injury
Graham et al., J Biol Chem 2006 : Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF, and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while TNF induced AP-1 activation increased
Afonso et al., Free Radic Biol Med 2006 : In agreement with these findings, EMSA shows a TNF-alpha induced increase in AP-1 and a decrease in Sp1 DNA binding
Lee et al., Life Sci 2006 : Emodin was determined to inhibit TNF alpha induced activation of AP-1 promoter, an important nuclear transcription factor in MMP-1 expression
Skayian et al., Life Sci 2006 : It was concluded that TNF-alpha activates NF-kappaB and AP-1 and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 )
Tsou et al., Toxicol Appl Pharmacol 2007 : We also demonstrated that intracellular glutathione does not modulate the activation of MAPKs and/or their downstream AP-1 induced by lower TNF-alpha ... Although AP-1 activation by the lower TNF-alpha was not detected in our systems, we could not rule out the possible involvement of transiently activated MAPKs/AP-1 in the regulation of TNF-alpha induced adhesion molecule expression
Nakao et al., Biochem Biophys Res Commun 2007 : Endogenous TNFalpha in pOCs induced c-Fos and NFATc1
Yamashita et al., J Biol Chem 2007 : We report that RANKL and TNF can induce osteoclast formation directly from NF-kappaB p50/p52 double knockout ( dKO ) osteoclast precursors when either c-Fos or NFATc1 is expressed
Sandur et al., Free Radic Biol Med 2007 : The suppression of TNF induced AP-1 activation by curcumin was also reversed by glutathione
Kawauchi et al., Biol Pharm Bull 2007 : cPrG.HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) alpha and phorbol myristate acetate ( PMA )
Srivastava et al., J Biol Chem 2007 : Furthermore, overexpression of a dominant negative mutant of TAK1 blocked the TNF-alpha induced expression of MMP-9 and activation of NF-kappaB and AP-1
Kanda et al., Am J Physiol Cell Physiol 2007 : Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha induced NF-kappaB and AP-1 activities or IFN-gamma induced NF-kappaB and STAT1 activities ... Histamine induced c-Fos mRNA expression alone or together with TNF-alpha , whereas it did not further increase c-Jun mRNA levels enhanced by TNF-alpha ... These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced hBD-2 production dependent on NF-kappaB, AP-1 , or STAT1 in human keratinocytes
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Yao et al., J Biol Chem 2008 (Bone Resorption) : TNF induces IL-1 expression and activates c-Fos , a transcription factor required in OCPs for osteoclast formation ... TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss
Takada et al., Mol Pharmacol 2008 (Neoplasms) : TNF is a potent inducer of activator protein-1 (AP-1) , and flavopiridol abrogated this activation in a dose- and time dependent manner ... Flavopiridol also inhibited the TNF induced induction of intercellular adhesion molecule-1, c-Myc, and c-Fos , all known to mediate tumorigenesis
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Herbein et al., Curr HIV Res 2008 : Since tumor necrosis factor alpha (TNFalpha) activates NF-kappaB and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages ... We observed that exogenous Nef and TNFalpha synergistically activate NF-kappaB and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ), and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages
Lee et al., Oncol Rep 2008 (MAP Kinase Signaling System...) : The transactivation of TNF-alpha stimulated NF-kappaB, AP-1 and Sp-1 were inhibited by U0126 and SB203580 treatment
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Mukhopadhyay et al., Toxicol Lett 2008 (MAP Kinase Signaling System) : TNF-alpha induces activating protein 1 (AP-1) activation via phosphorylation of mitogen activated protein kinases ( MAPKs )
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Kim et al., Molecules (Basel, Switzerland) 2008 (Breast Neoplasms) : Therefore, we further examined the effects of BBR on TNF-alpha induced AP-1 DNA binding activity which is a downstream target of ERK and p38 ... Our data showed that TNF-alpha induced AP-1 DNA binding activity was inhibited by BBR
Yogesha et al., J Immunol 2009 (Arthritis, Experimental...) : We found that IL-3 prevented TNF-alpha induced c-fos nuclear translocation and AP-1 DNA binding activity
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : 3 h after resuscitation, pulmonary capillary leakage and wet/dry weight ratio, levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and lung microscopic and ultrastructural histological changes were measured
Li et al., Inhal Toxicol 2009 : Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs
Wang et al., Inflammation 2009 (Inflammation...) : Three hour after resuscitation, bacterial translocation ( BT ), intestinal permeability, ileal levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and ileal microscopic and ultrastructural histological changes were measured
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Shyu et al., J Biomed Sci 2009 : The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity, while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha
Yin et al., Biomed Pharmacother 2009 (Breast Neoplasms) : Using luciferase reporter assays, we demonstrated that TNF-alpha significantly increased activator protein-1 (AP-1) transcriptional activity in the MCF7 cells
Nijboer et al., Stroke 2009 (Cerebral Infarction...) : When NF-kappaB was inhibited after neonatal cerebral HI, JNK/AP-1 activity was increased and required for increased TNF-alpha expression
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta, inhibited the activation of NF-kappaB and AP-1 , and improved lung histopathology
Arancibia et al., J Cell Mol Med 2011 : Cells expressing a PI3K mutant ( p85-dominant negative, DN ; p85 d478-511 ) and exposed to Pam ( 3 ) -Cys-Ser-Lys ( 4 ) in the presence or absence of dexamethasone, showed enhanced tumour necrosis factor ( TNF ) a expression while AP-1 and NF-?B transcriptional activity were repressed
Yang et al., Atherosclerosis 2010 : In cultured human aortic endothelial cells, TNF-alpha increased ET-1 through AP-1 and NF-kappaB, whereas MPA attenuated it by reducing both AP-1 and NF-kappaB DNA binding activities ... N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Sullivan et al., J Cell Mol Med 2009 : TNF-alpha induced increased levels of c-Jun and C-Fos in the nucleus accompanied by phosphorylation of c-Jun ... Together, these results suggest that TNF-alpha induces expression and DNA binding of AP-1 resulting in increased transcription of the TGF-beta(1) gene
Wang et al., J Med Invest 2010 (MAP Kinase Signaling System...) : Strategies that neutralize TNF-alpha as well as inhibitors of MAPK-NF-kappa B- and/or AP-1 dependent pathways may be useful for suppressing the MMP-9 effect and thus preventing multiple organ failure in severe influenza
Park et al., Int J Mol Med 2011 : GM3 synthase gene expression markedly suppressed the TNF-a stimulated transcriptional activity of activator protein-1 (AP-1) and nuclear factor-?B ( NF-?B ), which are the controlling factors of MMP-9 expression
Seidel et al., Schweiz Med Wochenschr 2010 : PDGF-BB and TNF-a activated AP-1 , which was also inhibited by DMF
Kim et al., Vascul Pharmacol 2012 (Atherosclerosis...) : Furthermore, sulforaphane inhibited NK-?B and AP-1 activation induced by TNF-a
Tsou et al., J Cell Biochem 2012 (Osteoarthritis) : TNF-a mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 Ab, thioredoxin, SP600125, and SB203580
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012 (Asthma...) : In human ASM ( HASM ) cells, TNF-a induces CD38 expression through activation of MAPKs, NF-?B, and AP-1 , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects
Koo et al., Cell Biol Int 2013 : TNF-a increased DNA binding activity of AP-1 and NF-?B, whereas both AP-1 and NF-?B decoy oligodeoxynucleotides downregulated TNF-a induced MCP-1 mRNA expression ... MPA and Syk inhibitor attenuated TNF-a induced DNA binding activity of NF-?B and AP-1
Yang et al., Biochem Pharmacol 2013 : Finally, we showed that, in H9c2 cells, TNF-a stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not
Lengyel et al., Biochim Biophys Acta 1995 : Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors
Tran-Thi et al., Hepatology 1995 : The results indicate a direct participation of NF-kappa B in the regulation of TNF-alpha synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively
Klampfer et al., Mol Cell Biol 1994 : Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter
Adcock et al., Life Sci 1994 : The interaction of the transcription factors, activator protein 1 (AP-1) and nuclear factor kappa from B cells ( NF kappa B ) with DNA and glucocorticoid receptors was analysed by gel mobility shift assays following stimulation by tumour necrosis factor alpha (TNF alpha) and a phorbol ester ( PMA ) that activates protein kinase C. PMA and TNF alpha both caused significant ( 180-340 % ) increases in AP-1 and NF kappa B DNA binding which peaked at 15 minutes and decreased to a constant elevated level at between 1-3 hrs and was sustained for 24hrs
Brach et al., Leukemia 1993 (Leukemia, Myeloid, Acute) : The mitogenic response of AML blasts to tumor necrosis factor-alpha requires functional c-jun/AP-1
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha , and IL-1 beta, cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture
Zhao et al., Mol Endocrinol 1996 : These results suggest that TNF alpha , probably acting through ceramide formation, stimulates the binding of both c-fos and c-jun to the AP-1 element upstream of exon 1.4
Marks et al., Am J Physiol 1996 : We found that epidermal growth factor (EGF) and tumor necrosis factor-alpha (TNF-alpha) transiently stimulate an increase in Fos protein that precedes stimulation of the gastrin promoter
Wang et al., Surgery 1998 (Carcinoma, Hepatocellular) : TNF-alpha increased c-jun and junD mRNA and c-Jun and JunD protein levels, as well as AP-1 binding activity
Shau et al., Biochem Biophys Res Commun 1998 : Tumor necrosis factor-alpha (TNF) activates the expression of activator protein-1 (AP-1) responsive genes ... We show here that over-expression of TxP-1 blocks TNF induced AP-1 activation in endothelial ECV304 cells, which was demonstrated by three independent experimental protocols : electromobility shift assay with AP-1 oligonucleotide probe ; reporter gene expression with AP-1 binding site, and interleukin-8 production, which is dependent on AP-1
Manna et al., J Immunol 1998 : TNF induced activation of another nuclear transcription factor, AP-1 , was suppressed by IL-13 ... Thus, overall, these results demonstrate that IL-13 is a potent inhibitor of TNF mediated activation of NF-kappa B, AP-1 , and apoptosis, which may contribute to its previously described immunosuppressive and anti-inflammatory effects
Lakshminarayanan et al., J Biol Chem 1998 : H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells ... H2O2 activated AP-1 but not NF-kappaB in A549, whereas TNFalpha activated AP-1 as well as NF-kappaB ... In HMEC-1, TNFalpha activated NF-kappaB but not AP-1 , while H2O2 did not activate either transcription factor ... Supershift analysis revealed H2O2 as well as TNFalpha induced AP-1 complexes containing c-Fos and JunD
Rahman et al., J Biol Chem 1999 : Gel shift and supershift analysis showed that TNF-alpha increased AP-1 DNA binding which was predominantly formed by dimers of c-Jun