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LEP — NOS3

Text-mined interactions from Literome

Okuya et al., Endocrinology 2001 : Moreover, 5 nM leptin reduced the triglyceride content and suppressed inducible nitric oxide synthase mRNA expression in incubated islets
Goetze et al., Hypertension 2002 : Both PPARgamma-ligands inhibited leptin stimulated Akt and eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Mehebik et al., Am J Physiol Cell Physiol 2005 : Furthermore, leptin induces NOS III phosphorylation at Ser ( 1179 ) and Thr ( 497 ), but not when adipocytes are pretreated with H-89 or U0126
Zerani et al., J Endocrinol 2005 : Leptin receptor expression and in vitro leptin actions on prostaglandin release and nitric oxide synthase activity in the rabbit oviduct ... In this study, we have examined the presence and the distribution of receptors for leptin ( Ob-R ) in the oviduct of rabbits, and the effects of leptin on the release of prostaglandin ( PG ) F2alpha and PGE2 and on the activity of nitric oxide ( NO ) synthase ( NOS ) by oviducts cultured in vitro
Otero et al., Arthritis Res Ther 2005 : Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes : synergistic effect of leptin with interleukin-1
Slomiany et al., Inflammopharmacology 2008 : Moreover, the stimulatory effect of leptin on the acinar cell cNOS activity was inhibited not only by PP2, but also by Akt inhibitor, SH-5, while wortmannin had no effect
Slomiany et al., J Physiol Pharmacol 2008 : Moreover, the stimulatory effect of leptin on the mucosal cells cNOS activity was inhibited not only by PP2, but also by Akt inhibitor, SH-5
Korda et al., Am J Physiol Heart Circ Physiol 2008 (Disease Models, Animal...) : In obesity, leptin increases eNOS expression and decreases intracellular l-arginine, resulting in eNOS an uncoupling and depletion of endothelial NO and an increase of cytotoxic ONOO ( - )
Procopio et al., Endocrinology 2009 : Leptin stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein ... We hypothesized that leptin effect on eNOS activation in human aortic endothelial cells might be blunted by direct interaction with human recombinant CRP ... Small interfering RNAs ( siRNAs ) were used to knock down expression of alpha1- or alpha2-AMPK in transient transfection assay to evaluate which is involved in this pathway and whether leptin effect on eNOS activation in human aortic endothelial cells might be blunted by direct interaction with human CRP ... By contrast, siRNA mediated knockdown of Akt1 did not affect AMPKalpha1 phosphorylation, but it abolished leptin induced phosphorylation of Akt-Ser ( 473 ) and eNOS-Ser ( 1177 ), suggesting that Akt functions downstream of AMPKalpha1 ... Preincubation of leptin with human recombinant CRP impaired leptin induced AMPK activation, eNOS-Ser ( 1177 ) phosphorylation, eNOS activity, and intracellular cGMP accumulation
Mehebik-Mojaat et al., J Cell Biochem 2009 (Insulin Resistance) : We examined insulin and leptin induced nitric oxide synthase (NOS) activity, protein amount and NOS III phosphorylation at Ser ( 1179 ) in isolated epididymal adipocytes from rat, in the presence or not of inhibitors of kinases implicated in insulin or leptin signaling pathways ... Insulin or leptin induced NOS III phosphorylation at Ser ( 1179 ) leading to increased NO production in rat adipocytes, in agreement with our previous observations
Donato et al., Endocrinology 2010 : Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
Singh et al., Atherosclerosis 2011 (Atherosclerosis) : The effect of increased caveolin-1 expression on leptin dependent activation of ERK1/2 and eNOS was determined by Western blot analysis
Sansbury et al., Circ Res 2012 (Disease Models, Animal...) : Overexpression of eNOS did not affect food consumption or diet induced changes in plasma cholesterol or leptin levels, yet plasma triglycerides and fatty acids were decreased