Wei et al., Am J Physiol Endocrinol Metab 2011
:
After the gene is upregulated, Nr0b2 can feed back and repress FoxO1- and Sirt1 activated G6pc and Pdk4 gene expression
Wang et al., J Clin Invest 2011
(Hyperglycemia...) :
We found that Sirt1 positively regulates transcription of the gene encoding Rictor, triggering a cascade of phosphorylation of Akt at S473 and Foxo1 at S253 and resulting in decreased transcription of the gluconeogenic genes glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase ( Pepck )