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EPHB2 — LEPR

Text-mined interactions from Literome

Byun et al., Neurobiol Dis 2011 (Body Weight...) : Consistent with this possibility, exposure of hypothalamic cells to zinc activated Erk-1/2 and induced Lepr expression in an Erk dependent manner
Mancuso et al., J Immunol 2012 (Klebsiella Infections...) : Ablation of leptin receptor mediated ERK activation impairs host defense against Gram negative pneumonia ... In this report, we assessed leptin receptor mediated ERK activation, a pathway that was ablated in the l/l mouse through a mutation of the tyrosine 985 residue in the leptin receptor, to determine its role in host defense against bacterial pneumonia in vivo and in alveolar macrophage ( AM ) antibacterial functions in vitro ... These results demonstrate that leptin receptor mediated ERK activation plays an essential role in host defense against bacterial pneumonia and in leukocyte antibacterial effector functions