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EPHB2 — TCF21
Text-mined interactions from Literome
Yoshizumi et al., Jpn J Pharmacol 2000
:
The
ERK1/2 activation was
followed by an increase in
transcription factor activator protein-1 DNA binding activity
Wang et al., J Biol Chem 2002
:
Superoxide mediates shock wave induction of
ERK dependent osteogenic
transcription factor ( CBFA1 ) and mesenchymal cell differentiation toward osteoprogenitors
Ying et al., J Neurosci 2002
:
BDNF-LTP was further coupled to
ERK dependent phosphorylation of the
transcription factor cAMP response element binding protein
Wang et al., J Biol Chem 2004
(Neovascularization, Pathologic) :
Ras induction of superoxide activates
ERK dependent angiogenic
transcription factor HIF-1alpha and VEGF-A expression in shock wave stimulated osteoblasts
Mao et al., Eur J Neurosci 2004
:
In a further attempt to evaluate the
role of active
ERK1/2 in activating a downstream
transcription factor cAMP response element binding protein ( CREB ), NMDA, AMPA, and kainate were found to increase CREB phosphorylation
Kim et al., Arch Pharm Res 2004
:
Several reports indicate that the activation of extracellular signal regulated kinase (
ERK )
induces microphthalmia associated
transcription factor ( MITF ) degradation
Ingram et al., Kidney Int 2004
(MAP Kinase Signaling System) :
Erk induces increases in activator protein-1 (AP-1)
transcription factor activity which may augment mesangial cell proliferation and ECM protein production
Song et al., J Biol Chem 2005
:
IFN-gamma induced
ERK1/2 phosphorylation and subsequently the
transcription factor early gene
response 1, which in turn up-regulated p35 expression and increased cyclin dependent kinase 5 (Cdk5) activity
Haberny et al., Neuroscience 2005
:
These results point to specific neuroadaptations in the NAc of FR rats whereby D-1 DA receptor stimulation leads to increased NMDA NR1 subunit phosphorylation and consequent increases in NMDA receptor dependent CaMK II and ERK1/2 signaling, and increased NMDA
receptor/ERK1/2 dependent phosphorylation of the nuclear
transcription factor , CREB
Molina et al., J Biol Chem 2005
:
Furthermore, D-site peptides, which are able to potently inhibit
ERK2 mediated phosphorylation of the Elk-1
transcription factor ( IC50= 3 microm ), are relatively poor inhibitors of ERK2 mediated phosphorylation of MITF, exhibiting > 15-fold selectivity for inhibition of Elk-1 versus MITF
Maclachlan et al., Int J Radiat Biol 2005
(Radiation Injuries) :
In vitro exposure to FGF-20 increased expression of the Nrf2
transcription factor and oxygen radical scavenging enzymes such as MnSOD,
activated signal transduction pathways (
ERK and Akt ) and resulted in increased survival of irradiated cells in vitro
Gelain et al., Cell Signal 2006
:
In this work, we report that, in Sertoli cells, retinol ( 7 microM ) induces the Src dependent activation of ERK1/2 MAPK and the
ERK1/2 mediated phosphorylation of the
transcription factor CREB
Park et al., Neurosci Lett 2006
(Neuroblastoma) :
The mitogen activated protein kinase/extracellular signal regulated kinase (
MAPK/ERK )
activates a
transcription factor CREB
Zhang et al., J Immunol 2006
:
Blocking the activation of
ERK prevented histone phosphorylation and
transcription factor binding to the IL-10 promoter
Cortez et al., Am J Physiol Heart Circ Physiol 2007
:
IL-17 induced p38 MAPK and
ERK1/2 activation , and inhibition by SB-203580 and PD-98059 blunted IL-17 mediated
transcription factor activation and MMP-1 expression
Kilanczyk et al., Biochem Biophys Res Commun 2009
:
We also demonstrate that
CacyBP/SIP-ERK1/2 interaction
inhibits phosphorylation of the Elk-1
transcription factor in vitro and in the nuclear fraction of NB2a cells
Xu et al., Biochem Biophys Res Commun 2009
:
We now show in both HEK cells and human microglial cells that the induction of Cyr61 protein expression by the human FP receptor utilizes a novel mechanism involving the activation of Ras and Raf followed by a
MEK/ERK independent
activation of
Tcf signaling
Biyashev et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
We demonstrate that
Erk5 phosphorylation
allows activation of PPARgamma
transcription factor by displacement of SMRT co-repressor
Cook et al., Am J Surg 2010
(Thyroid Neoplasms) :
Xanthohumol inhibits the neuroendocrine
transcription factor achaete-scute complex-like 1, suppresses proliferation, and
induces phosphorylated
ERK1/2 in medullary thyroid cancer
Bae et al., Nephrol Dial Transplant 2011
:
HHE mediated accumulation of ROS may
induce redox-sensitive
transcription factor , NF-?B, through activation of
ERK and JNK, resulting in cellular apoptosis in HK-2 cells
Wu et al., Mol Cancer Res 2011
(Breast Neoplasms...) :
LPA stimulated p21 via LPA ( 1 ) and LPA ( 2 ) receptors and
Erk dependent activation of the CCAAT/enhancer binding protein beta
transcription factor independent of p53
Yen et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
PKA, PI3K, and
ERK inhibitors abolished PGE2- and cAMP induced c-Fos and MMP-9 up-regulation, and ERK activation was
required for the binding of activator protein 1 (AP-1)
transcription factor to the MMP-9 promoter
Zhang et al., Mol Cell Biochem 2013
(MAP Kinase Signaling System) :
ROS production leads to
activation of
ERK1/2 and then activation of the NF-?B
transcription factor
Janknecht et al., Mol Cell Biol 1996
:
Analysis of the
ERK stimulated ETS
transcription factor ER81
Yoshizumi et al., Br J Pharmacol 1998
:
4. Gel-mobility shift analysis revealed that the
ERK1/2 activation was
followed by an increase in
transcription factor activator protein-1 DNA binding activity in HCASMCs