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LEP — PPARA

Text-mined interactions from Literome

Wang et al., J Biol Chem 1999 : We conclude that in normal adipocytes leptin directly decreases FAS expression, increases PPARalpha and the enzymes of FFA oxidation, and stimulates a novel form of lipolysis in which glycerol is released without a proportional release of FFA
Ajuwon et al., J Nutr Biochem 2003 : Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue
Bendinelli et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : We pre treated C2C12 cells with AACOCF3, a specific inhibitor of cytosolic phospholipase A2 (cPLA2), an enzyme that supplies ligands to PPARs, and found that it abrogates leptin induced PPAR DNA binding activity
Suzuki et al., Mol Cell Biol 2007 (Neoplasms, Muscle Tissue) : Our data thus suggest that the activation of and changes in the subcellular localization of alpha2AMPK are required for leptin induced stimulation of fatty acid oxidation and PPARalpha gene expression in muscle cells
Catalano et al., Am J Pathol 2011 (Breast Neoplasms...) : PPAR? mediated repression of leptin gene involved the recruitment of nuclear receptor corepressor protein and silencing mediator of retinoid and thyroid hormone receptors corepressors on the glucocorticoid responsive element site in the leptin gene expression regulatory region in the presence of glucocorticoid receptor and PPAR? ... In addition, PPAR? ligands inhibited leptin signaling mediated by MAPK/STAT3/Akt phosphorylation and counteracted leptin stimulatory effect on estrogen signaling
Lu et al., Fish Physiol Biochem 2012 : Using the IRS-PI(3)K-specific inhibitor W1628, we found that only the Lep induced downregulation of PPAR? was reduced