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CXCL10 — TLR3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCL10 → TLR3 (increases, TLR3 Translocation, CXCL10 Activity)
  Evidence: Poly(I:C), an analog of viral dsRNA and a TLR3 ligand,

Text-mined interactions from Literome

Rudd et al., J Virol 2005 : Targeting the expression of TLR3 with small interfering RNA decreased synthesis of IP-10/CXCL10 and CCL5 but did not significantly reduce levels of CXCL8
Park et al., Glia 2006 : TLR3 mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes : differential signaling mechanisms of TLR3 induced IP-10 and IL-8 gene expression
Qian et al., Blood 2007 : Blockade of IFN-alpha/beta inhibits IP-10 production by TLR agonist activated regulatory DCs
Maire et al., Biochem Biophys Res Commun 2008 : Both TLR3 and RIG-I are required for CXCL10 expression
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., Cell Microbiol 2009 : In addition, TLR2 , Dectin-1 and, to an extent, TLR4 are essential for the MU-mediated expression of CXCL8 , CCL2 and LL-37 in keratinocytes
Song et al., Viral Immunol 2011 : Taken together, the results suggest that IL-8, IP-10 , and GRO-a are predominantly induced in respiratory epithelial cells infected with influenza A viruses, and that TLR-5 and TLR-3 are involved in the stimulation of virus infected respiratory epithelial cells
Kwissa et al., Blood 2012 : Furthermore, all TLR-Ls induced rapid ( 3-8 hours ) expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L mobilized the CD14 ( + ) CD16 ( + ) and CD14 ( dim ) CD16 ( ++ ) monocytes, and only TLR7/8-L and TLR9-L induced activation of myeloid dendritic cells ( mDCs ) and plasmacytoid DCs ( pDCs ), production of IP-10 and type-I IFN, and expression of type-I IFN related and chemokine genes in the blood
Abe et al., J Virol 2012 : In this study, we examined the role of the Toll-like receptor ( TLR ) pathway on IP-10 production in cells replicating HCV
Ostvik et al., Inflamm Bowel Dis 2013 (Colitis, Ulcerative...) : Enhanced expression of CXCL10 in inflammatory bowel disease : potential role of mucosal Toll-like receptor 3 stimulation ... The TLR3-ligand poly ( I:C ) markedly increased release of CXCL10 in colonic epithelial cell lines, suggesting a TLR3 mediated CXCL10 release from mucosal epithelial cells in IBD patients
George et al., Biochem Biophys Res Commun 2012 (Hypertension, Pulmonary) : Using specific TLR ligands, we found that activation of TLRs 3 and 4 resulted in IL-8 release by human pulmonary artery smooth muscle cells but that only TLR3 stimulation resulted in IP10 and endothelin-1 release
Sharma et al., J Leukoc Biol 2013 : Our findings reveal a previously unrecognized role for S1P in regulating TLR induced CXCL8 secretion from human T cells
Imaizumi et al., Am J Nephrol 2013 : Using an RNA interfering technique, involvement of TLR3 , IFN-ß, melanoma differentiation associated gene 5 ( MDA5 ) or retinoic acid-inducible gene-I (RIG-I) in ISG56 expression, and of ISG56 in the expression of MDA5, RIG-I, CXCL10 and CCL5 was examined