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CA2 — RHO

Text-mined interactions from Literome

Singleton et al., Cell Motil Cytoskeleton 2002 (Calcium Signaling) : CD44v10 interaction with Rho-kinase (ROK) activates inositol 1,4,5-triphosphate ( IP3 ) receptor mediated Ca2+ signaling during hyaluronan ( HA ) -induced endothelial cell migration
Senin et al., Adv Exp Med Biol 2002 : Ca2+ dependent control of rhodopsin phosphorylation : recoverin and rhodopsin kinase
Sakurada et al., Circ Res 2003 : Ca2+ dependent activation of Rho and Rho kinase in membrane depolarization induced and receptor stimulation induced vascular smooth muscle contraction
Okigaki et al., Proc Natl Acad Sci U S A 2003 : In addition, chemokine stimulation of inositol ( 1, 4, 5 ) triphosphate production and Ca2+ release, as well as integrin induced activation of Rho and phosphatidyl inositol 3 kinase, were compromised in Pyk2-/- macrophages
Janssen et al., Am J Physiol Lung Cell Mol Physiol 2004 : KCl also caused marked stimulation of Rho and ROCK activities, and both these changes were suppressed by nifedipine or by removal of external Ca2+
Liu et al., Am J Physiol Lung Cell Mol Physiol 2005 : Regulation of Rho/ROCK signaling in airway smooth muscle by membrane potential and [Ca2+ ] i
Wang et al., Biochem J 2006 : We demonstrated previously that membrane depolarization and excitatory receptor agonists such as noradrenaline induce Ca2+ dependent Rho activation in VSM ( vascular smooth muscle ), resulting in MP ( myosin phosphatase ) inhibition through the mechanisms involving Rho kinase mediated phosphorylation of its regulatory subunit MYPT1
Rosenbaum et al., Neuron 2006 (Calcium Signaling...) : Calnexin is essential for rhodopsin maturation, Ca2+ regulation , and photoreceptor cell survival
Woodsome et al., J Cell Sci 2006 : Phosphorylation of myosin light chain ( MLC ) and contraction of differentiated smooth muscle cells in vascular walls are regulated by Ca2+ -dependent activation of MLC kinase, and by Rho-kinase- or protein-kinases-C dependent inhibition of MLC phosphatase ( MLCP )
Yoshioka et al., Mol Pharmacol 2007 : Consistent with our previous observations showing that ionomycin and membrane depolarization induced Rho activation in vascular smooth muscle tissues in a Ca2+ dependent manner, ionomycin induced contraction was dependent on Rho and Rho-kinase ... These observations indicate that PI3K-C2alpha is necessary for Ca2+ induced Rho- and Rho kinase dependent negative regulation of MLCP and consequently MLC phosphorylation and contraction
Huang et al., Cell Signal 2009 (Breast Neoplasms) : Activation of choline kinase by extracellular Ca2+ is Ca ( 2+ ) -sensing receptor, Galpha12 and Rho dependent in breast cancer cells
Tyminski et al., Biochemistry 1982 : Analysis of the fraction of Ca2+ released and the fraction of bleached rhodopsin per vesicle showed that a single bleached rhodopsin per vesicle is necessary and sufficient for Ca2+ release
Gorodovikova et al., FEBS Lett 1994 : Rhodopsin phosphorylation in the reconstituted system consisting of urea washed photoreceptor membranes, rhodopsin kinase and recoverin is regulated by Ca2+ : the process takes place at low [Ca2+ ] but is suppressed at high [Ca2+ ]
Lagnado et al., Nature 1994 : We now report that lowering intracellular [Ca2+ ] reduces the catalytic rhodopsin activity produced by light
Senin et al., FEBS Lett 1995 : We have found that rhodopsin phosphorylation by purified rhodopsin kinase, which does not depend on free [Ca2+ ] in the absence of recoverin, is regulated by Ca2+ in the presence of both forms of the recombinant protein ... In the presence of Ca2+ , both forms of recoverin taken at saturated concentrations cause an almost equal inhibition of rhodopsin phosphorylation
Sato et al., J Biochem 1997 : After light-activation of rhodopsin kinase, the S-modulin/Ca2+ complex binds to the activated kinase and inhibits the phosphorylation of rhodopsin
Fu et al., FEBS Lett 1998 : The effects of the Rho-kinase inhibitor, Y-27632 [ 1 ] on Ca2+-sensitization of force induced by arachidonic acid ( AA ), phorbol 12,13-dibutyrate ( PDBu ), GTPgammaS, and by the stable thromboxane analog, 9,11-dideoxy-9alpha,11alpha-methanoepoxy-PGF2alpha ( U-46619 ), were determined in alpha-toxin permeabilized smooth muscles ... We conclude that ( i ) AA induces Ca2+-sensitization through dual mechanisms, one mediated by Rho-kinase ( or a related kinase ), and ( ii ) Rho-kinase is not required for phorbol ester induced Ca2+-sensitization