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NOTCH2 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ando et al., Oncogene 2003
(Arthritis, Rheumatoid) :
We found that
TNF induced the expression of Notch-1,
Notch-4 , and Jagged-2 in RSF
Quillard et al., PloS one 2009
:
In conclusion,
TNF signaling
activates Notch2 that sensitizes ECs to apoptosis via modulation of the key apoptosis regulator survivin
Jiao et al., Clin Dev Immunol 2012
(Arthritis, Rheumatoid) :
The aim of this paper was to investigate whether
Notch signaling mediated
TNF-a induced cytokine production of cultured fibroblast-like synoviocytes ( FLSs ) from RA
Zhang et al., J Biol Chem 2012
(Inflammation...) :
Importantly, overexpression of constituted active form of Notch1 ( NICD1 ) and
Notch2 ( NICD2 )
suppressed production of TLR4 triggered proinflammatory cytokines such as
TNF-a and IL-6 but promoted production of antiinflammatory cytokine IL-10, which is dependent on the PEST domain of NICD