◀ Back to CD79B
CD19 — CD79B
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BCR signaling pathway:
CD19 (CD19)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
CD19 (CD19)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, activates)
O'Rourke et al., Immunity 1998
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cherukuri et al., J Immunol 2004
:
Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and
CD19/CD21 complexes fail to partition into lipid rafts and
enhance BCR signaling from rafts
Ishiura et al., Eur J Immunol 2010
(Lymphoma, B-Cell) :
BCR engagement
induced differential tyrosine phosphorylation, as CD19-Y ( 513 ) phophorylation occurred first, and
CD19-Y ( 482 ) phosphorylation was delayed and transient ... Different BCR isotypes exhibited distinct patterns of CD19 phosphorylation :
IgG-BCR ligation
resulted in faster phosphorylation of
CD19-Y ( 513 ) and more intense phosphorylation of CD19-Y ( 391 ) than IgM-BCR ligation
Sato et al., Proc Natl Acad Sci U S A 1997
:
Ligation of
CD19 and CD22 in vivo is likely to positively and negatively
regulate BCR signaling, respectively, because CD19 crosslinking was more efficient than BCR crosslinking at inducing Vav phosphorylation