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CHUK — ROCK1
Text-mined interactions from Literome
Wei et al., Mol Pharmacol 2006
:
Further studies showed that LPS down-regulated Rho and ROCK activity, whereas IL-1beta increased them, suggesting a negative
role of Rho and
ROCK signaling, which is regulated in contrary manners by IL-1beta and LPS, in
IKK/NF-kappaB activation
Rafferty et al., Cell Immunol 2012
:
ROCK inhibition also suppressed IL-1 induced JNK phosphorylation in both cell lines, but high levels of the inhibitor
had no significant effect on IL-1 stimulated Caco-2 I?Ba phosphorylation and degradation or
IKK phosphorylation and kinase activity