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ANXA1 — CAPN3
Text-mined interactions from Literome
Pareek et al., Proc Natl Acad Sci U S A 2006
(Inflammation...) :
Increased
calpain activity in sensory neurons after inflammation
resulted in the cleavage of
p35 to p25, which forms a more stable complex with Cdk5 and, consequently, leads to elevation of Cdk5 activity
Kamei et al., J Biol Chem 2007
(Neurodegenerative Diseases) :
Suppression of
calpain dependent cleavage of the CDK5 activator
p35 to p25 by site-specific phosphorylation
Seyb et al., J Mol Neurosci 2007
:
Recent evidence supports A beta induction of a
calpain dependent cleavage of the cyclin dependent kinase 5 (cdk5) regulatory protein
p35 that contributes to tau hyperphosphorylation and neuronal death
Chen et al., Brain Res 2008
(Alzheimer Disease...) :
The cleavage of
p35 to p25,
mediated by
calpain and calcium, caused CDK5 dislocation and subsequently p25/CDK5 induced tau hyperphosphorylation, which disrupted the cytoskeleton and resulted in neuronal death