Relaix et al., Proc Natl Acad Sci U S A 2000
:
The observation that Pw1/Peg3 is necessary for the p53 apoptotic response suggests a pivotal role for this gene in determining cell death versus survival
Yamaguchi et al., J Biol Chem 2002
(Hypoxia-Ischemia, Brain) :
In human neuroblastoma derived SK-N-SH cells, Peg3/Pw1 mRNA expression is enhanced remarkably at 24 h post-hypoxia, when p53 protein expression was also enhanced at high levels ... Adenovirus mediated high dose p53 overexpression induced Peg3/Pw1 mRNA expression
Johnson et al., J Biol Chem 2002
:
We report here that Peg3/Pw1 is up-regulated after DNA damage in cortical neurons in a p53 dependent manner
Su et al., Oncogene 2005
(Cell Transformation, Neoplastic) :
Phosphorylation of p53 by GADD34 is one mechanism by which it inhibits growth and PEG-3 could prevent GADD34 induced p53 phosphorylation