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FGFR2 — NCAM2

Text-mined interactions from Literome

Hinsby et al., J Neurochem 2004 : This activation was blocked by inhibitors of both FGFR and Fyn, indicating that NCAM activates FGFR signaling in a manner distinct from FGF2 stimulation, and regulates ShcA phosphorylation by the concerted efforts of the NCAM/FGFR as well as the NCAM/Fyn signaling pathway
Kiselyov et al., J Neurochem 2005 : In this review, we analyse the structural basis of the homophilic interactions of the neural cell adhesion molecule ( NCAM ) and the NCAM mediated activation of the fibroblast growth factor receptor ( FGFR ) ... We provide evidence that FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAM-FGFR and FGF-FGFR interactions
Povlsen et al., J Neurochem 2008 : Furthermore, NCAM-180 mediated EGFR down-regulation requires NCAM homophilic binding and interactions of the cytoplasmic domain of NCAM-180 with intracellular interaction partners, but does not require NCAM mediated fibroblast growth factor receptor activation
Carafoli et al., J Mol Biol 2008 : Activation of the fibroblast growth factor receptor ( FGFR ) by neural cell adhesion molecule ( NCAM ) is essential for NCAM mediated neurite outgrowth
Kochoyan et al., Protein Sci 2008 : Structural basis for the activation of FGFR by NCAM
Kiselyov et al., Neurosci Lett 2009 : C3, a synthetic peptide binding to the Ig1 module of the neural cell adhesion molecule ( NCAM ) has previously been identified and shown to inhibit NCAM homophilic binding and NCAM mediated activation of the fibroblast growth factor ( FGF ) receptor ( FGFR ) ... Here we show that in the absence of NCAM, C3 can bind and activate FGFR, whereas in the presence of NCAM , C3 inhibits the NCAM stimulated FGFR activation without activating FGFR on its own
Chernyshova et al., J Neurosci 2011 : The neural cell adhesion molecule promotes FGFR dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones
Zecchini et al., EMBO Mol Med 2011 (Carcinoma...) : This pro-malignant function of NCAM is mediated by its interaction with fibroblast growth factor receptor ( FGFR ) ... Our results point to NCAM mediated stimulation of FGFR as a novel mechanism underlying EOC malignancy and indicate that this interplay may represent a valuable therapeutic target