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HBZ — JUN
Text-mined interactions from Literome
Matsumoto et al., Oncogene 2005
(Leukemia-Lymphoma, Adult T-Cell) :
In the course of investigating HBZ function, we found that
HBZ reduced the steady-state levels of
c-Jun , and the levels were restored by treatment with a proteasome inhibitor ... Together, this indicates that
HBZ promotes
c-Jun degradation through a proteasome dependent pathway ... These results suggest dual
effects of
HBZ on the suppression of
AP-1 activity by inhibiting c-Jun function, which may contribute to the dysregulation of cell proliferation
Hivin et al., Nucleic Acids Res 2006
:
Like c-Fos, HBZ ( HTLV-I bZIP factor ) is able to interact with c-Jun but differs considerably from c-Fos in its ability to activate AP-1-responsive genes since
HBZ rather
inhibits transcriptional activity of
c-Jun
Isono et al., J Biol Chem 2008
:
Although most proteasomal substrates are targeted for degradation via conjugation of polyubiquitin chains, we show that ubiquitination is not required for
HBZ mediated proteasomal degradation of
c-Jun
Clerc et al., Virology 2009
:
In conclusion, we demonstrate that the repression of c-Jun activity in vivo is mainly due to the
HBZ-SP1 mediated sequestration of
c-Jun to the HBZ-NBs