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JUN — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wong et al., Mol Cell Biol 1999
:
Smad3-Smad4 and AP-1 complexes synergize in transcriptional
activation of the
c-Jun promoter by
transforming growth factor beta
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro ... In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Imai et al., Infect Immun 2000
:
Since TGF-beta1 pretreatment inhibited LPS stimulated expression of c-fos and c-jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 (AP-1), a heterodimer of c-Fos and c-Jun, in the cells,
TGF-beta1 inhibition of CD14 expression may be a
consequence of downregulation of
AP-1
Finlay et al., J Biol Chem 2000
:
Transforming growth factor-beta 1-induced activation of the ERK
pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor ... Dependence of ERK/AP-1 activation on bFGF induction was demonstrated by inhibition of
TGF-beta1 induced
ERK/AP-1 activation when conditioned medium from TGF-beta1 treated cells was incubated with bFGF neutralizing antibody
Dennler et al., J Biol Chem 2000
:
c-Jun inhibits
transforming growth factor beta mediated transcription by repressing Smad3 transcriptional activity
Junn et al., J Immunol 2000
:
NAC also reduced
TGF-beta1 induced
AP-1 binding activity, which is involved in IL-6 gene expression
Palcy et al., J Bone Miner Res 2000
:
Protein kinase C ( PKC ) - and protein tyrosine kinase ( PTK ) -dependent pathways have been implicated in both
TGF-beta1 signaling and
AP-1 gene
regulation
Rodríguez-Barbero et al., FEBS Lett 2002
:
TGF-beta1 induced p38 and extracellular signal regulated kinase ( ERK ) 1/2 phosphorylation whereas no effect on
Jun N-terminal kinase phosphorylation was observed
Samson et al., Surgery 2002
:
TGF-beta1 also
induces c-Jun , a potential proapoptotic transcription factor ... These data demonstrate that
TGF-beta1 induces
c-Jun , but c-Jun is not proapoptotic in hepatocytes
Zhou et al., Zhonghua Yi Xue Za Zhi 2002
:
To clarify whether the
activating protein-1 (AP-1) is
involved in the transcriptional regulation of expression of oxidized low density lipoprotein ( Ox-LDL ) induced
transforming growth factor (TGF)-beta(1) gene and further to investigate the possible signal transduction pathway in the cultured mesangial cells ( MsCs )
Arsura et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by
TGF-beta1 inhibits
AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Bamba et al., Am J Physiol Gastrointest Liver Physiol 2003
:
The EMSAs demonstrated that both IL-1beta and
TGF-beta1 induced
AP-1 activation within 2 h after stimulation, and a blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta- and TGF-beta1 induced IL-11 mRNA expression
Utsugi et al., Am J Respir Cell Mol Biol 2003
:
TGF-beta1 activated
c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase, but not ERK in HFL-1 cells
Park et al., Oncogene 2003
(Prostatic Neoplasms) :
TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the
JNK-c-Jun-AP-1 signaling
plays a pivotal role in
TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the
TGF-beta1 induction of IL-6 in an
AP-1 dependent manner
Wang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001
:
Heat shock
induces elevated expression of hsp,
c-Jun , CLK-1 gene while decreases expression of integrin alpha-4 and
transforming growth factor beta
Luettich et al., Molecular cancer 2003
(MAP Kinase Signaling System) :
TGFbeta1 activates
c-Jun and Erk1 via alphaVbeta6 integrin ... We conclude that
TGFbeta1 activates
c-Jun via the MEKK1/p38 MAP kinase pathway and influences cytoskeletal organization
Naso et al., J Invest Dermatol 2003
:
These analyses demonstrated that
transforming growth factor beta1 stimulation of Col7a1 transcription is
dependent on a putative interaction between Smads and
AP1
Baroni et al., J Cutan Pathol 2004
(Psoriasis) :
We found that M. furfur up-regulates
transforming growth factor-beta1 ( TGF-beta1 ), integrin chain, and HSP70 expression in human keratinocytes via
AP-1 dependent mechanism
Guo et al., Diabetes 2004
:
PPAR-gamma overexpression inhibited
TGF-beta 1-induced fibronectin expression as well as the
activation of
AP-1 ... 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ), a natural PPAR-gamma ligand, also inhibited TGF-beta1 induced fibronectin expression by suppressing
AP-1 activation by
TGF-beta 1 ... In conclusion, pioglitazone
inhibits TGF-beta 1-induced fibronectin expression by inhibiting
AP-1 activation dependent on PPAR-gamma, while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Kim et al., Invest Ophthalmol Vis Sci 2005
:
To evaluate the
effects of
TGF-beta1 and doxycycline on production of gelatinase MMP-9 and activation of Smad,
c-Jun N-terminal kinase (JNK) , extracellular regulated kinase (ERK), and p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells
Stanley et al., Biochem Biophys Res Commun 2005
(Neovascularization, Pathologic...) :
These effects are
caused by the inhibition of constitutively active
AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and
TGF-beta1 from PC-3 cells
Kaur et al., J Biol Chem 2005
(Carcinoma, Hepatocellular) :
X-linked inhibitor of apoptosis (XIAP) inhibits
c-Jun N-terminal kinase 1 ( JNK1 ) activation by
transforming growth factor beta1 ( TGF-beta1 ) through ubiquitin mediated proteosomal degradation of the TGF-beta1 activated kinase 1 (TAK1)
Lee et al., J Immunol 2006
:
Our results suggest that IL-1beta stimulated transcription of
TGF-beta1 is temporally
regulated by NF-kappaB and
AP-1 and involves histone hyperacetylation at distinct promoter sites
Chiarpotto et al., Biofactors 2005
(Fibrosis) :
Moreover, we demonstrate that HNE can indeed contribute to the onset of fibrosis by stimulating
AP-1 binding to DNA and consequently
inducing TGFbeta1 expression, since thiol-group reagents, such as N-ethylmaleimide and 4- ( chloro-mercuri ) -benzenesulfonic acid, that down-modulate HNE entrance and localisation inside the cell, prevent both phenomena
Harding et al., Kidney Int 2006
:
TGFbeta1 increased transcription by approximately 50 % and
activated both
AP-1 and NF-kappaB
Hu et al., Lung 2006
:
In addition, dominant negative mutant c-Jun ( TAM67 ) downregulated
TGF-beta1 induced
AP-1 transactivation and alpha-SMA expression ... In additional, PD98059 but not SB203580 inhibited the
AP-1 DNA binding activity
induced by
TGF-beta1
Santibañez et al., FEBS Lett 2006
(Cell Transformation, Neoplastic) :
TGF-beta1 induces JNK phosphorylation,
c-Jun transactivation and AP1 activation
Zhang et al., Am J Pathol 2006
:
Furthermore, Smad3 blockade specifically inhibited
activation of the transcription factor
AP-1 by
TGF-beta1 , whereas PD98059 prevented TGF-beta1 dependent nuclear factor-kappaB activation
Dhandapani et al., J Neurosci Res 2007
(Brain Neoplasms...) :
Induction of
transforming growth factor-beta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is
mediated by MEK/ERK signaling and
AP-1 activation
Lai et al., Int J Dermatol 2007
:
The cellular morphology, mitogenic activities, expression of keratinocyte growth factor (KGF) and
transforming growth factor beta-1 ( TGF-beta1 ), and
activation of extracellular regulated kinase (ERK) and
c-Jun N-terminal kinase (JNK) signaling pathways of dermal fibroblasts were studied after ultrasound treatment
Matsuzaki et al., Hepatology 2007
(Carcinoma, Hepatocellular...) :
Conversely,
transforming growth factor beta ( TGF-beta )
activates not only TGF-beta type I receptor ( TbetaRI ) but also
c-Jun N-terminal kinase (JNK) , which convert the mediator Smad3 into two distinctive phosphoisoforms : C-terminally phosphorylated Smad3 ( pSmad3C ) and linker phosphorylated Smad3 ( pSmad3L )
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008
:
To study the
role of
activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and
transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Fichtner-Feigl et al., Cancer Res 2008
(Carcinoma...) :
Here, we show that in two tumor models ( the CT-26 metastatic colon cancer and the 15-12RM fibrosarcoma regressor models ), this counter-surveillance mechanism requires the expression of a novel IL-13 receptor, IL-13R alpha(2), on Gr-1 ( intermediate ) cells, because down-regulation of IL-13R alpha(2) expression or the
activator protein-1 signal generated by the receptor via in vivo administration of specific small interfering RNA or decoy oligonucleotides
leads to loss of
TGF-beta(1) production
Seppänen et al., Acta Obstet Gynecol Scand 2008
(Carcinoma, Endometrioid...) :
We were able to show that IFN-gamma,
TGF-beta(1) and TNF-alpha all
increased the binding activity of transcription factor
AP-1 ( AP-1 )
Lee et al., Oncogene 2009
:
A promoter deletion analysis suggested that
activating protein 1 (AP-1) plays a role in
TGFbeta1 gene transactivation, which was corroborated by the observation that a deficiency of the G-proteins decreased the AP-1 activity, whereas their activation enhanced it
Han et al., J Korean Med Sci 2009
(MAP Kinase Signaling System) :
Aldosterone induced
TGF-beta1 expression is
regulated by mitogen activated protein kinases and
activator protein-1 in mesangial cells ... We examined the
role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and
activator protein-1 (AP-1) in the aldosterone induced
TGF-beta(1) expression in rat mesangial cells ... We examined the
role of extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ),
c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) in the aldosterone induced
TGF-beta(1) expression in rat mesangial cells
Wu et al., J Am Soc Nephrol 2009
(Diabetes Mellitus, Experimental...) :
Finally, pharmacologic and dominant negative inhibition of EGFR blocked glucose induced activation of PKC-beta1, phosphorylation of AktS473,
activation of
AP-1 , and upregulation of
TGF-beta1
Geismann et al., Cancer Res 2009
(Adenocarcinoma...) :
Both
TGF-beta1- and PMF induced L1CAM expression were independent of Smad proteins but
required c-Jun NH ( 2 ) -terminal kinase activation leading to the induction of the transcription factor Slug
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009
:
To investigate the expression of CTGF, CTGF mRNA, NF-kappaB and
AP-1 induced by
TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The
effects of
TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and
AP-1 were evaluated with Western blot
Markovics et al., J Biol Chem 2010
(Inflammation) :
Transcription of the
transforming growth factor beta activating integrin beta8 subunit is
regulated by SP3,
AP-1 , and the p38 pathway
Uría et al., J Biol Chem 1998
:
Finally, by using electrophoretic mobility shift assays and antibody supershift analysis, we propose that c-Fos,
c-Jun , and JunD may
play major roles in the collagenase-3 activation by
TGF-beta1 in human fibroblasts
Han et al., J Pharmacol Exp Ther 1998
:
Under identical condition, we examined the
effect of
TGF-beta1 on the activity of nuclear factor AT ( NF-AT ), nuclear factor kappaB (NF-kappaB),
activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression ... Electrophoretic mobility shift assays showed that
TGF-beta1 markedly
increased NF-AT, NF-kappaB and
AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells