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EPHB1 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Ephrin B/EPHB1 complex (EFNB3_EFNB2_EFNB1-EPHB1) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Src (SRC) (modification, collaborate) Vindis et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1 complex (EFNB3_EFNB2_EFNB1-EPHB1) → Src (SRC) (modification, collaborate) Vindis et al., J Cell Biol 2003
  Evidence: assay, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → FAP1 (PTPN13) (modification, collaborate) Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Ephrin B/EPHB1/Src/Paxillin complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-PXN) (modification, collaborate)
  Vindis et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Paxillin (PXN) (modification, collaborate) Vindis et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src/Paxillin complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-PXN) → Paxillin (PXN) (modification, collaborate) Vindis et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database EPHB forward signaling: GRB2 (GRB2) → Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: GRB2 (GRB2) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → p52 SHC (SHC1) (modification, collaborate) Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: p52 SHC (SHC1) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Palmer et al., Mol Cell 2002
  Evidence: assay
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Palmer et al., Mol Cell 2002
  Evidence: assay
• Reactome Reaction: SRC → EPHB1 (direct_complex)
• Reactome Reaction: SRC → EPHB1 (indirect_complex) Palmer et al., Mol Cell 2002
• Reactome Reaction: SRC → EPHB1 (reaction) Marignani et al., J Cell Biol 2001, Palmer et al., Mol Cell 2002, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Zhang et al., J Neurosci 2005, Cowan et al., Neuron 2005, Tolias et al., Proc Natl Acad Sci U S A 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: SRC — EPHB1 (interaction, mapped from kegg_pathways)
• STRING interaction: EPHB1 — SRC (interaction, mapped from grid)

Text-mined interactions from Literome

Vindis et al., J Cell Biol 2003 : Here we demonstrate that activated EphB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal regulated kinase ( ERK ) activation
Georgakopoulos et al., EMBO J 2006 : Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB induced Src phosphorylation and signaling ... The mechanism, however, by which EphB activates Src in the ephrinB expressing cells is unknown