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GIT1 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: GIT1 → SRC (directlyIncreases, GIT1 Activity) Haendeler et al., J Biol Chem 2003*
  Evidence: Here we show that the GPCR kinase-interacting protein-1 (GIT1) is a substrate for c-Src that undergoes tyrosine phosphorylation in response to angiotensin II (AngII) and EGF in vascular smooth muscle and 293 cells.
• OpenBEL Selventa BEL large corpus: GIT1 → SRC (directlyIncreases, GIT1 Activity) Yin et al., Mol Cell Biol 2004*
  Evidence: Here we show that the GPCR kinase-interacting protein 1 (GIT1) is a substrate for c-Src that associates with MEK1 in vascular smooth-muscle cells and human embryonic kidney 293 cells.
• Reactome Reaction: GIT1 → SRC (indirect_complex) Zhang et al., J Cell Biol 2003, Segura et al., Nat Neurosci 2007
• Reactome Reaction: GIT1 → SRC (reaction) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Zhang et al., J Neurosci 2005, Segura et al., Nat Neurosci 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — GIT1 (in vitro) Haendeler et al., J Biol Chem 2003*
• IRef Hprd Interaction: SRC — GIT1 (in vivo) Haendeler et al., J Biol Chem 2003*
• IRef Ophid Interaction: SRC — GIT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

van Nieuw Amerongen et al., Circ Res 2004 : Thrombin stimulated GIT1 tyrosine phosphorylation with a time course similar to FAK phosphorylation in a Rho kinase- and Src dependent manner
Yin et al., J Biol Chem 2005 : Because Src is required for both GIT1 tyrosine phosphorylation and focal adhesion disassembly, we studied the effects of Src on GIT1-ERK1/2 interactions
Wang et al., Arterioscler Thromb Vasc Biol 2009 : Because GIT1 is a substrate of c-Src, and podosome formation is c-Src dependent , we hypothesized that GIT1 plays an important role in VEGF induced EC podosome formation and cell migration