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HRAS — SRC

Pathways - manually collected, often from reviews:

• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → RAS (HRAS) (modification, activates)
• KEGG GnRH signaling pathway: SRC → HRAS/KRAS/NRAS (protein-protein, indirect effect)
• NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma: RAS family/GTP/PI3K complex (PIK3CA-PIK3R1-HRAS_KRAS_HRAS_KRAS_NRAS) → Src (SRC) (modification, activates) Zhang et al., EMBO J 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CXCR3-mediated signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → Src (SRC) (modification, collaborate) Bonacchi et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database CXCR3-mediated signaling events: Src (SRC) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Bonacchi et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → HRAS/GTP complex (HRAS) (modification, activates) Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → HRAS/GDP complex (HRAS) (modification, activates) Estrada et al., Endocrinology 2003*
  Evidence: mutant phenotype, assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — HRAS (in vitro) Thornton et al., J Biol Chem 2003*
• IRef Intact Interaction: SRC — HRAS (direct interaction, pull down) Thornton et al., J Biol Chem 2003*
• IRef Ophid Interaction: SRC — HRAS (aggregation, confirmational text mining) Thornton et al., J Biol Chem 2003*
• IRef Ophid Interaction: SRC — HRAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Thornton et al., J Biol Chem 2003 : We suggest that H-Ras negatively regulates Src phosphorylation of NR2A and retention of NR2A into the synaptic membrane leading to inhibition of NMDA receptor function
Marais et al., EMBO J 1995 : We show that in mammalian cells activation of p74Raf-1 by oncogenic Src requires pp60Src to be myristoylated and the ability of p74Raf-1 to interact with p21Ras-GTP