Gene interactions and pathways from curated databases and text-mining

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NFKB1 — RAF1

Pathways - manually collected, often from reviews:

  • KEGG Tuberculosis: RAF1 → NFKB1/RELA (protein-protein, activation)

Text-mined interactions from Literome

Nakayama et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : Raf1 also regulates the activation of NF-kappaB
Fan et al., Oncogene 2007 : Further studies revealed that Raf1 positively regulates the ability of SF to stimulate NF-kappaB activity and cell protection ... The ability of Raf1 to stimulate NF-kappaB activity was not due to the classical Raf1 -- > MEK1/2 -- > ERK1/2 pathway
Chang et al., Pharmacol Res 2009 : In this study, we further investigated the role of Raf-1 in YC-1 induced nuclear factor-kappaB (NF-kappaB) activation and COX-2 expression in A549 cells
Burgess et al., CNS Neurol Disord Drug Targets 2010 (Disease Models, Animal...) : The persistent activation of cRaf-1 can activate the proinflammatory factor NFkappaB and consequently, upregulate the expression of several of its downstream factors such as the amyloid precursor protein (APP), Cox-2 and iNOS
Li et al., EMBO J 1995 : The same results were obtained in vivo using transfection assays ; 14-3-3 enhanced both c-Raf-1- and Raf-1 kinase domain stimulated expression of AP-1- and NF-kappa B-dependent reporter genes and accelerated Raf-1 kinase domain triggered differentiation of PC12 cells
Folgueira et al., J Virol 1996 : Because of the similarity between HIV and Ras-Raf induced NF-kappa B activation in monocytic cells, we next tested whether HIV induced NF-kappa B activation was mediated by the Ras-Raf signal transduction pathway