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LCK — PTK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → FAK (PTK2) (modification, activates) Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PTK2 — LCK (in vitro) Berg et al., J Immunol 1997*
• IRef Hprd Interaction: PTK2 — LCK (in vivo) Berg et al., J Immunol 1997*

Text-mined interactions from Literome

Torigoe et al., Blood 1992 (Leukemia, Myeloid, Acute...) : Recently, it was reported that the IL-2R ( whose p75 beta-subunit shares sequence homology with a known murine IL-3R subunit and a common beta-subunit of the human IL-3R and granulocyte-macrophage colony stimulating factor [ GM-CSF ] receptors ) can physically associate with and regulate the activity of the SRC-family PTK , p56-LCK
Ryan et al., J Biol Chem 1995 : First, the protein tyrosine kinase inhibitor herbimycin A blocked LCF induced p56lck activation but had no effect on the LCF induced motile response
Minami et al., EMBO J 1993 : This suggests that the association of p56lck with the IL-2R beta chain, despite its low stoichiometry, is required for the activation of cellular p56lck PTK upon IL-2 stimulation
Bell et al., J Exp Med 1996 : An Src-like protein tyrosine kinase , p56lck, coprecipitates with CD2, and perturbation of CD2 by monoclonal antibodies results in an increase in the activity of p56lck , suggesting that an interaction with p56lck contributes to CD2 mediated signaling
Phipps et al., AIDS 1996 : The role of the gp120-CD4-Lck interaction in HIV related PTK activation was determined using gp 120 treated Jurkat cells and HIV-infection of JCaM 1.6 cells, a Jurkat derived cell line that lacks p56lck
al-Ramadi et al., J Immunol 1996 : In this report, we demonstrate that specific inhibition of Lck expression in Th2 cells, in the presence of normal levels of functional Fyn PTK , has profound consequences on multiple events following TCR stimulation, including an altered pattern of tyrosine phosphorylated substrates, defective phosphorylation of TCR-zeta and ZAP-70, defective Ca2+ mobilization, and a approximately 90 % reduction in proliferative responses to antigenic and mitogenic stimuli
Binstadt et al., Immunity 1996 : These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells
Lu et al., J Immunol 1998 : Ligation of the TCR or CD28 induces activation of phosphatidylinositol 3-kinase (PI3K), the TEC family protein tyrosine kinase , EMT/ITK/TSK ( EMT ), and the SRC family tyrosine kinase, LCK