◀ Back to HDAC1
CTNNB1 — HDAC1
Pathways - manually collected, often from reviews:
-
BioCarta multi-step regulation of transcription by pitx2:
Pitx2/HDAC complex (PITX2-HDAC1)
→
beta-catenin (CTNNB1)
(modification, collaborate)
-
BioCarta multi-step regulation of transcription by pitx2:
beta-catenin (CTNNB1)
→
HDAC/LEF1 complex (HDAC1-LEF1)
(modification, activates)
-
BioCarta multi-step regulation of transcription by pitx2:
Pitx2/HDAC complex (PITX2-HDAC1)
→
beta-catenin (CTNNB1)
(modification, collaborate)
-
BioCarta multi-step regulation of transcription by pitx2:
beta-catenin (CTNNB1)
→
Pitx2/HDAC complex (PITX2-HDAC1)
(modification, activates)
-
BioCarta multi-step regulation of transcription by pitx2:
beta-catenin (CTNNB1)
→
HDAC (HDAC1)
(modification, activates)
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1/LEF1 complex (HDAC1-LEF1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HDAC1 (HDAC1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HDAC1/LEF1 complex (HDAC1-LEF1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Billin et al., Mol Cell Biol 2000*
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/TBLR1/TBL1 complex (TCF4-CTNNB1-TBL1XR1-TBL1X)
→
TLE1/HDAC1 complex (TLE1-HDAC1)
(modification, collaborate)
Li et al., Nat Cell Biol 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/TBLR1/TBL1 complex (TCF4-CTNNB1-TBL1XR1-TBL1X)
→
TCF4/TLE1/HDAC1 complex (TCF4-TLE1-HDAC1)
(modification, collaborate)
Li et al., Nat Cell Biol 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin/TBL1/TBLR1 complex (TBL1X-TBL1XR1-CTNNB1)
→
TLE1/HDAC1 complex (TLE1-HDAC1)
(modification, collaborate)
Li et al., Nat Cell Biol 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin/TBL1/TBLR1 complex (TBL1X-TBL1XR1-CTNNB1)
→
TCF4/TLE1/HDAC1 complex (TCF4-TLE1-HDAC1)
(modification, collaborate)
Li et al., Nat Cell Biol 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
HDAC1-HDAC2 (HDAC1/HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/HDAC1-HDAC2 complex (TCF7L2-HDAC1_HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1-HDAC2 (HDAC1/HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
TCF4/HDAC1-HDAC2 complex (TCF7L2-HDAC1_HDAC2)
(modification, collaborate)
Ye et al., Nat Neurosci 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Kioussi et al., Cell 2002*
Evidence: physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin (CTNNB1)
→
HDAC1/PITX2 complex (HDAC1-PITX2)
(modification, collaborate)
Kioussi et al., Cell 2002*
Evidence: physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
HDAC1 (HDAC1)
→
beta catenin/PITX2 complex (CTNNB1-PITX2)
(modification, collaborate)
Kioussi et al., Cell 2002*
Evidence: physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
beta catenin/PITX2 complex (CTNNB1-PITX2)
→
HDAC1/PITX2 complex (HDAC1-PITX2)
(modification, collaborate)
Kioussi et al., Cell 2002*
Evidence: physical interaction, other species
-
Reactome Reaction:
HDAC1
→
CTNNB1
(reaction)
Omer et al., Biochem Biophys Res Commun 1999, Chen et al., Genes Dev 1999, Chen et al., Gene 2000, Graham et al., Cell 2000, Poy et al., Nat Struct Biol 2001, Brantjes et al., Biol Chem 2002, Song et al., Mol Cell Biol 2004, Daniels et al., Nature structural & molecular biology 2005, Arce et al., BMC cancer 2009, Molenaar et al., Cell 1996, Behrens et al., Nature 1996, Pinto et al., J Biol Chem 1996, van de Wetering et al., Cell 1997, Korinek et al., Mol Cell Biol 1998, Levanon et al., Proc Natl Acad Sci U S A 1998, Chen et al., Mol Cell Biol 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC1
—
CTNNB1
(physical association, affinity chromatography technology)
Iioka et al., FEBS Lett 2009*
-
IRef Biogrid Interaction:
HDAC1
—
CTNNB1
(physical association, affinity chromatography technology)
Vietor et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
HDAC1
—
CTNNB1
(physical association, affinity chromatography technology)
Billin et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
HDAC1
—
CTNNB1
(physical association, affinity chromatography technology)
Iguchi et al., J Biol Chem 2007*
-
IRef Innatedb Interaction:
HDAC1
—
CTNNB1
(unknown, -)
Billin et al., Mol Cell Biol 2000*
-
IRef Intact Interaction:
HDAC1
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Iioka et al., FEBS Lett 2009*
Text-mined interactions from Literome
Ye et al., Nat Neurosci 2009
:
HDAC1 and HDAC2
regulate oligodendrocyte differentiation by disrupting the
beta-catenin-TCF interaction
Neufeld et al., Adv Exp Med Biol 2009
(Colorectal Neoplasms) :
This down-regulation of nuclear
beta-catenin activity by APC most likely
involves nuclear sequestration of beta-catenin from the transcription complex as well as interaction of APC with transcription corepressor
CtBP