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BMP4 — GSK3B
Text-mined interactions from Literome
Deng et al., Am J Physiol Lung Cell Mol Physiol 2010
(Hypertension...) :
Unlike epidermal growth factor,
BMP-4 , TGF-beta1, 5-HT, and ET-1 each
increased smooth muscle cell size, contractile protein expression, fractional cell shortening, and
GSK-3beta phosphorylation ... Expression of a non-phosphorylatable
GSK-3beta mutant
blocked BMP-4- , TGF-beta1-, 5-HT-, and ET-1 induced cell size enlargement, suggesting that GSK-3beta phosphorylation is required and sufficient for cellular hypertrophy
Fukuda et al., Differentiation 2010
:
By contrast, inhibition or stimulation of
GSK3beta activity
resulted in either stimulation or suppression of ALP activity, respectively, in the presence of
BMP-4