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IL12A — IL23A
Text-mined interactions from Literome
Puccetti et al., Crit Rev Immunol 2002
:
However, although both cytokines enhance the Th1 costimulatory functions of APCs, and
IL-23 does
induce IL-12 from APCs, their effects, which in part overlap, can be differentiated from one another
Ireland et al., Viral Immunol 2005
(Encephalitis, Viral...) :
Furthermore, these data indicate that
IL-23 is not
acting redundantly in the absence of
IL-12 during VSV induced encephalitis
Shan et al., Cell Mol Immunol 2006
(Carcinoma...) :
IL-23 also
promoted the production of Th1 cytokines such as IFN-gamma,
IL-12 and TNF-alpha
Hao et al., Cancer Immunol Immunother 2006
(Neoplasms) :
IL-23 can
enhance the proliferation of memory T cells and the production of IFN-gamma,
IL-12 and TNF-alpha from activated T cells
Nakae et al., J Leukoc Biol 2007
:
We found that
IL-23 or IL-17 can suppress Th1 cell differentiation in the
presence of exogenous
IL-12 in vitro
Gerosa et al., J Exp Med 2008
:
DC priming with interferon (IFN) gamma strongly increased
IL-12 production, but was not
required for
IL-23 production and inhibited IL-23 production induced by beta-glucan
Kim et al., J Immunol 2008
(Neoplasms, Experimental) :
IL-12p40 is a natural antagonist which
inhibits IL-12- and IL-23 mediated biological activity by blocking the binding of
IL-12/23 to their receptors
Schulz et al., J Immunol 2008
(Necrosis...) :
To analyze the
role of
IL-23 in the absence of
IL-12 , low doses of S. Enteritidis were administered to p35 ( -/- ) mice ( lacking IL-12 ), p35/19 ( -/- ) mice ( lacking IL-12 and IL-23 ), p35/40 ( -/- ) mice ( lacking IL-12, IL-23, and homodimeric IL-12p40 ), or p35/IL-17A ( -/- ) mice ( lacking IL-12 and IL-17A )
Lyakh et al., Immunol Rev 2008
:
Mycobacterium tuberculosis and yeast zymosan induce
IL-23 , but in the absence of other stimuli, no
IL-12 is
induced in human dendritic cells (DCs)
Cooper et al., Immunol Rev 2008
(Tuberculosis) :
IL-23 can
induce IFN-gamma responses in the lung if
IL-12 is not present, but its major role is in supporting the IL-17 response within the lung
Stewart et al., Cancer Cell 2009
(Neoplasms) :
In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine
IL-23 in macrophages but
inhibits the antitumor cytokine
IL-12 in dendritic cells
Uemura et al., J Immunol 2009
:
This study demonstrates that the activation of human iNKT cells by their specific ligand alpha-galactosylceramide
enhances IL-12p70 while inhibiting the
IL-23 production by monocyte derived dendritic cells, and in turn down regulating the IL-17 production by memory CD4 ( + ) Th cells
Rovedatti et al., Gut 2009
(Colitis, Ulcerative...) :
IL23 and IL1beta plus IL6 had no effect on IBD LPMC production of IL17 ; however,
IL12 markedly
increased IFNgamma production and decreased IL17 production
Haas et al., Eur J Immunol 2009
:
IL-12 and IL-18
induced IFN-gamma and
IL-23 induced IL-17A production by NK1.1+ or CCR6+ gammadelta T cells, respectively
van de Wetering et al., PloS one 2009
(Salmonella Infections) :
Both IFN-gamma and GM-CSF enhanced
IL-23 production by monocytes in
response to TLR agonists, as well as induced
IL-12 production ... The
IL-23 induced cytokines
allow for the subsequent production of
IL-12 and amplify the IFN-gamma production in the type-1 cytokine pathway
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited IL-1beta,
IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27,
IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Donini et al., Prostate 2012
(Prostatic Neoplasms) :
LNCaP
enhance IL-1ß,
IL-23 , IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases
IL-12 production through NADPH oxidase unrelated mechanisms
Reay et al., Cancer Gene Ther 2012
(Fibrosarcoma) :
These results demonstrate that although significant antitumor effects are achieved by intratumoral injection of adenovirus expressing either scIL-23 or IL-12 alone and that
IL-23 requires endogenous
IL-12 for maximum antitumor benefit, the combined use of these cytokines provides no additive or synergistic effect
McBerry et al., J Immunol 2012
(Disease Models, Animal...) :
p38 MAPK activation and
IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2
suppressed TLR induced
IL-12/23p40 production
Wang et al., J Virol 2013
(Hepatitis C, Chronic) :
We found that Tim-3 and
IL-23p19 are highly expressed and that
IL-12p35 is
inhibited in human CD14 ( + ) monocytes, while IL-17 expression is upregulated in CD4 ( + ) T cells, in chronically HCV infected individuals compared to healthy subjects
Carrión et al., Neuroimmunomodulation 2013
:
VIP decreased
IL-12p35 mRNA
upregulation by poly ( I:C ) and
IL-23p19 transcripts in LPS treated FLS