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CEBPA — MYC

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: CEBPA → MYC (gene expression, missing interaction)
• KEGG Pathways in cancer: CEBPA → MYC (gene expression, missing interaction)
• NCI Pathway Database E2F transcription factor network: CEBPA/BRM/RB1/E2F4 complex (CEBPA-SMARCA2-RB1-E2F4) → MYC (MYC) (transcription, inhibits) Iakova et al., Cell 2003, Hiebert et al., Proc Natl Acad Sci U S A 1989
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — CEBPA (physical association, affinity chromatography technology) Tinel et al., J Hepatol 2003*
• IRef Hprd Interaction: MYC — CEBPA (in vitro) Tinel et al., J Hepatol 2003*
• IRef Hprd Interaction: MYC — CEBPA (in vivo) Tinel et al., J Hepatol 2003*
• IRef Ophid Interaction: MYC — CEBPA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Johansen et al., Mol Cell Biol 2001 : c-Myc is a critical target for c/EBPalpha in granulopoiesis ... Therefore, C/EBPalpha negative regulation of c-Myc is critical for allowing early myeloid precursors to enter a differentiation pathway ... This is the first report to demonstrate that C/EBPalpha directly affects the level of c-Myc expression and, thus, the decision of myeloid blasts to enter into the granulocytic differentiation pathway
Matsushita et al., Oncogene 2008 (Leukemia, Myeloid, Acute) : These findings suggest that the ectopic expression of C/EBPepsilon, as well as C/EBPalpha , can induce the monocytic differentiation of myelomonocytic leukemic cells with MLL-fusion gene through the downregulation of Myc , thus providing insight into the development of novel therapeutic approaches
Antonson et al., Eur J Biochem 1995 (Lipoma) : Myc inhibits CCAAT/enhancer binding protein alpha-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region ... To determine whether Myc is involved in the modulation of the expression of the CCAAT/enhancer binding protein alpha ( C/EBP alpha ) gene, we used both stable cell lines overexpressing Myc and transient co-transfection assays ... We also show that enforced expression of Myc in mouse hibernoma HIB-1B cells dramatically repressed the expression of C/EBP alpha -- promoter-reporter fusion genes