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IL12B — TSLP
Text-mined interactions from Literome
Watanabe et al., Blood 2005
(Dermatitis, Atopic...) :
Human
TSLP promotes CD40 ligand induced
IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
Ito et al., J Exp Med 2005
:
Here we report that
TSLP induced human DCs to express OX40 ligand (OX40L) but not
IL-12
Tanaka et al., Clin Exp Allergy 2009
:
Although
TSLP alone did not
induce IL-23 production by DCs, poly ( I : C ) alone primed DCs for the production of IL-23, and a combination of TSLP and poly ( I : C ) primed DCs for further production of IL-23
Massacand et al., Proc Natl Acad Sci U S A 2009
(Strongylida Infections...) :
TSLP inhibited
IL-12p40 production in response to T. muris infection, and treatment of TSLPR ( -/- ) animals with neutralizing anti-IL-12p40 monoclonal antibody ( mAb ) was able to reverse susceptibility and attenuate IFN-gamma production ... Taken together, our data show that the primary function of
TSLP is to directly
suppress IL-12 secretion, thus supporting Th2 immune responses
Chu et al., J Allergy Clin Immunol 2013
(Hypersensitivity) :
We showed that experimental HDM induced allergic asthma and food allergy and anaphylaxis to peanut were associated with TSLP production but developed independently of TSLP, likely because these allergens functionally mimicked
TSLP inhibition of
IL-12 production and induction of OX40 ligand (OX40L) on DCs