Gene interactions and pathways from curated databases and text-mining

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CDKN1B — MYC

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of CCND2-CDK4-CDKN1B → MYC (increases) Bouchard et al., EMBO J 1999
    Evidence: We nowshow that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexesupon activation of Myc and that cyclin D2 is a direct target gene of Myc.

Text-mined interactions from Literome

Donjerković et al., Cell Growth Differ 1999 (Lymphoma, B-Cell) : CD40L, the calcium chelator 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid-acetoxymethyl ester, and cyclosporin A all prevented anti-IgM induced p27Kip1 accumulation, suggesting that both the decrease in c-Myc expression and an increase in free calcium are necessary for p27Kip1 up-regulation
Chandramohan et al., J Immunol 2004 : Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels
Old et al., Mol Cancer Res 2010 (Cell Transformation, Neoplastic...) : Skp2 directs Myc mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis