UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MYC

MYC — PPARGC1B

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: PPARGC1B → MYC (increases, MYC Activity, PPARGC1B Activity)
Evidence: in VHL-deficient renal cell carcinoma cells, HIF-1 can induce a decrease in respiration and mitochondrial biogenesis by negatively regulating c-myc activity and, thereby reducing the expression of the transcriptional coactivator protein PGC-1b, resulting in reduced cellular respiration [39].