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CASP3 — IRF5
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CASP3
→
IRF5
(increases, CASP3 Activity)
Evidence: TABLE V Selected genes up-regulated by IRF-5
Text-mined interactions from Literome
Fantuzzi et al., Eur J Immunol 2001
:
In conclusion,
IRF-1 regulates IL-18 production and activity mostly by modulating expression of
caspase-1 and IL-18BP
Suk et al., J Pharmacol Exp Ther 2003
:
Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting
caspase-11 activation,
interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Hu et al., J Biol Chem 2009
:
IRF-5 is involved in DR signaling upstream of caspase 8, in part because of an
IRF-5 dependent increase in
caspase 8 activation