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Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RPS6KA2
→
MAPK3
(directlyIncreases, RPS6KA2 Activity)
Pullen et al., Science 1998* Evidence: Etienne-Manneville and Hall (2003) used primary rat astrocytes in a cell migration assay to demonstrate that PAR6-PKC-zeta interacts directly with and regulates glycogen synthase kinase-3-beta (GSK3-beta; 605004) to promote polarization of the centrosome and to control the direction of cell protrusion. CDC42-dependent phosphorylation of GSK3-beta occurs specifically at the leading edge of migrating cells, and induces the interaction of APC (175100) protein with the plus ends of microtubules. Erk...