◀ Back to NFKB1
NFKB1 — TNIP3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wullaert et al., J Biol Chem 2007
:
Similar to the other ABINs,
ABIN-3 binds to A20 and
inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1, and 12-O-tetradecanoylphorbol-13-acetate ... Moreover, in vivo adenoviral gene transfer of
ABIN-3 in mice
reduced LPS induced
NF-kappaB activity in the liver, thereby partially protecting mice against LPS/D- ( + ) -galactosamine induced mortality
Verstrepen et al., J Cell Mol Med 2008
(Sepsis) :
We have previously identified A20 binding inhibitor of
NF-kappaB activation (
ABIN)-3 as an lipopolysaccharide (LPS)-inducible protein in monocytes that negatively regulates NF-B activation in response to tumour necrosis factor (TNF) and LPS ... This revealed that the LPS- and TNF-inducible expression of
ABIN-3 is
dependent on the binding of
NF-kappaB to a specific B site in the ABIN-3 promoter ... Altogether, these data indicate an important role for
NF-kappaB dependent gene expression of
ABIN-3 in the negative feedback regulation of TNF receptor and toll-like receptor 4 induced NF-kappaB activation
Verstrepen et al., Biochem Pharmacol 2009
:
Similar to A20, ABIN-1 and
ABIN-3 expression is
NF-kappaB dependent , implicating a potential role for the A20/ABIN complex in the negative feedback regulation of NF-kappaB activation