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DUSP1 — PRDX2

Text-mined interactions from Literome

Ho et al., Endocrinology 2007 : TSA at higher concentrations also inhibited the adrenergic induction of mapk phosphatase-1 (mkp-1) and inducible cAMP early repressor mRNAs
Hsu et al., Biochim Biophys Acta 2011 : TSA suppression of JNK and p38MAPK phosphorylation and subsequent COX-2 expression were restored by selective inhibition of MKP-1 using MKP-1 siRNA ... In addition, TSA caused an increase in MKP-1 phosphatase activity in HUVECs ... In conclusion, TSA may cause MKP-1 activation to dephosphorylate JNK and p38MAPK, leading to the downregulation of COX-2 in HUVECs stimulated by LPS, a proinflammatory stimulus
Williams et al., Ann N Y Acad Sci 2011 : These findings suggest that TSA upregulates the expression of C/EBP-ß and MKP-1 , which may downregulate pro-osteoclastogenic factors and signaling molecules, ultimately suppressing osteoclastogenesis