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IRF6 — PTX4

Text-mined interactions from Literome

Fan et al., Frontiers in bioscience : a journal and virtual library 2006 (Gram-Negative Bacterial Infections...) : The induction of these cytokines was significantly ( p < 0.05 ) suppressed by PTx. Glucan treatment alone had no effect on cytokine production but suppressed ( P < 0.05 ) LPS and SA induced cytokines. PTx further augmented ( p > 0.05 ) the inhibitory effect of glucan on the LPS and SA induced cytokine expression
Parhar et al., Mediators Inflamm 1993 : In the present study the effects of PTX on lipopolysaccharide (LPS) and cytokine induced T-cell and macrophage ( PhiM ) activation, and on natural killer ( NK ) cell and lymphokine activated killer ( LAK ) cell mediated cytotoxicity were examined
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS) , tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF ) ... Upon stimulation with TNF or LPS , HUVEC produced IL-8 and PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS