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ADORA3 — TNF

Text-mined interactions from Literome

Zhang et al., Biochem Pharmacol 2005 : The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes
Martin et al., J Pharmacol Exp Ther 2006 : Activation of the adenosine A3 receptor in RAW 264.7 cells inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha release by reducing calcium dependent activation of nuclear factor-kappaB and extracellular signal regulated kinase 1/2
Lee et al., Neurosci Lett 2006 (Encephalitis...) : Thus, we investigated the effect of adenosine and adenosine A3 receptor ligands on LPS induced tumor necrosis factor ( TNF-alpha ) production and its molecular mechanism in mouse BV2 microglial cells ... Taken together, these results suggest that adenosine A3 receptor activation suppresses TNF-alpha production by inhibiting PI 3-kinase/Akt and NF-kappaB activation in LPS treated BV2 microglial cells
Prabhakar et al., Int J Immunopharmacol 1995 : We examined the effects of adenosine A1 and A2 receptor agonists on LPS stimulated TNF alpha production by human monocytes isolated from peripheral blood
Lichtman et al., Hepatology 1994 : Dibutyryl cyclic AMP, prostaglandin E1, prostaglandin E2 and the adenosine A2-receptor agonist N-ethylcarboxyamideadenosine inhibited lipopolysaccharide stimulated tumor necrosis factor-alpha release by 83 %, 97 %, 90 % and 94 %, respectively, but inhibited peptidoglycan-polysaccharide stimulated tumor necrosis factor-alpha release by 52 %, 60 %, 45 % and 51 %, respectively ( p < 0.001 for each )
McWhinney et al., Eur J Pharmacol 1996 : Thus, the binding of adenosine receptor agonists to the adenosine A3 receptor interrupts the endotoxin CD14 receptor signal transduction pathway and blocks induction of cytokine TNF-alpha , revealing a novel cross-talk between the murine adenosine A3 receptor and the endotoxin CD14 receptor in J774.1 macrophages
Bowlin et al., Cell Mol Biol Incl Cyto Enzymol 1997 : Thus, the binding of adenosine receptor agonists to the adenosine A3 receptor interrupts the endotoxin CD14 receptor signal transduction pathway and blocks induction of cytokine TNF-alpha , revealing a novel cross-talk between the murine adenosine A3 receptor and the endotoxin CD14 receptor in J774.1 macrophages