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CDK1 — TNF

Text-mined interactions from Literome

Gaiotti et al., Mol Carcinog 2000 : Tumor necrosis factor-alpha promotes human papillomavirus ( HPV ) E6/E7 RNA expression and cyclin dependent kinase activity in HPV immortalized keratinocytes by a ras dependent pathway
Sérandour et al., Hepatology 2005 : Demonstration was also provided that EGF alone only promoted cell progression up to late G ( 1 ), whereas TNFalpha was necessary for G ( 1 ) /S transition and Cdk1 induction
Tsuji et al., Exp Cell Res 1993 : We observed that TNF induced CDC2 and CDK2 expression in early-passage quiescent WI-38 fibroblasts ... However, as cells approached senescence, their ability to induce CDC2 and CDK2, as well as stimulate DNA synthesis in response to TNF , progressively declined, with minimal to absent induction in senescent cells ... These results demonstrate that senescent cells are selectively deficient in TNF mediated induction of CDC2 and CDK2, genes crucial to DNA synthesis and mitosis