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P2RY2 — VCAM1
Text-mined interactions from Literome
Seye et al., J Biol Chem 2003
:
The
P2Y2 nucleotide receptor
mediates UTP induced
vascular cell adhesion molecule-1 expression in coronary artery endothelial cells ... Results indicated that the equipotent
P2Y2 receptor agonists UTP or ATP ( 1-100 microm )
stimulated the expression of
vascular cell adhesion molecule-1 ( VCAM-1 ) in human coronary artery endothelial cells ( HCAEC ) in a time- and dose dependent manner ... These findings suggest a novel
role for the
P2Y2 receptor in the p38- and Rho kinase dependent expression of
VCAM-1 that mediates the recruitment of monocytes by vascular endothelium associated with the development of atherosclerosis
Seye et al., J Biol Chem 2004
(Arteriosclerosis) :
The
P2Y2 nucleotide receptor
mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 ( KDR/Flk-1 ) ... RNA interference targeting VEGFR-2 or inhibition of VEGFR-2 tyrosine kinase activity abolishes
P2Y(2)R mediated
VCAM-1 expression ... Significantly, a dominant negative form of RhoA inhibited
P2Y(2)R mediated
VCAM-1 expression, whereas expression of dominant negative forms of Cdc42 and Rac1 had no effect
Baker et al., Mol Immunol 2008
:
Furthermore,
P2Y2R activation
mediated the up-regulation of
VCAM-1 expression in HSG cells leading to increased adherence of lymphocytic cells ... Inhibitors of EGFR phosphorylation and metalloprotease activity abolished
P2Y2R mediated
VCAM-1 expression and decreased lymphocyte binding to HSG cells ... These results suggest that
P2Y2R activation in salivary gland cells
increases the EGFR dependent expression of
VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS