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IL6 — UCN
Text-mined interactions from Literome
Kohno et al., J Clin Endocrinol Metab 2001
(Arthritis, Rheumatoid...) :
Urocortin stimulated IL-1beta and
IL-6 secretion by human peripheral blood mononuclear cells in vitro
Kageyama et al., Endocrinology 2003
(MAP Kinase Signaling System) :
In this cell line, both
Ucn and Ucn II induced accumulation of intracellular cAMP via corticotropin releasing factor receptor type 2beta and also
caused a significant increase in
IL-6 output levels
Huang et al., Cardiovasc Res 2003
(Coronary Disease) :
Stress induced
IL-6 release may, therefore, be at least partly
due to peripheral
Ucn and/or CRH, with Ucn possibly overcompensation for CRH deficiency
Kageyama et al., Endocrinology 2006
:
Urocortin induces
interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells ... We previously found that both
Ucn1 and -2 induced accumulation of intracellular cAMP via CRF ( 2beta ) receptor binding and significantly
increased IL-6 secretion by A7r5 aortic smooth muscle cells ... In the present study, we investigated
Ucn effects on
IL-6 gene expression and IL-6 synthesis in A7r5 aortic smooth muscle cells
Kageyama et al., Peptides 2007
:
Inhibitory effects of glucocorticoids on
urocortin mediated increases in
interleukin-6 gene expression in rat aortic smooth muscle cells ... We previously demonstrated that both
Ucn1 and Ucn2
increased IL-6 output levels in A7r5 aortic smooth muscle cells ... In the present study, we extended observations on stress or hormone induced changes in IL-6 gene expression in the cardiovascular system, and determined the effects of glucocorticoids on
Ucn mediated increases in
IL-6 mRNA levels, protein levels, and gene transcription activity in A7r5 cells ...
Ucn1 , Ucn2, and Ucn3 all
increased IL-6 mRNA levels via CRF receptor type 2
Huang et al., J Mol Endocrinol 2009
:
Urocortin induces
interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation ... Here, we show that neonatal rat cardiomyocytes express CRH-R2 by western blot analysis and
Ucn induces
interleukin-6 (IL-6) release in a time- and dose dependent fashion ... Ucn stimulates activation of ERK and p38 MAP kinases, while both MEK1 and p38 inhibitor block
Ucn induced
IL-6 release ...
Ucn also activates nuclear factor kappa B (NF-kappaB) and a NF-kappaB inhibitor
blocks Ucn induced
IL-6 release ... Finally, the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit
Ucn induced
IL-6 release, as well as activation of ERK, p38, and NF-kappaB ... These findings indicate that
Ucn induces
IL-6 synthesis and release from neonatal rat cardiomyocytes
Agnello et al., Am J Physiol 1998
:
In mice,
UCN ( 1 microg/mouse sc ) significantly reduced lipopolysaccharide (LPS) induced serum tumor necrosis factor (TNF) and interleukin (IL)-1beta levels in vivo but did not
affect serum
IL-6